Korean J Psychopharmacol.
2003 Dec;14(4):377-386.
Dopamine Transporter Density of the Basal Ganglia as a Predictor of Methylphenidate Response in Children with Attention Deficit Hyperactivity Disorder-A [123I]IPT SPECT Study
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea.
- 2Division of Nuclear Medicine, Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Kwandong University, Gangneung, Korea.
Abstract
OBJECTIVE
Dopamine transporter is a key regulator of dopamine neurotransmission and is also the primary target of methylphenidate. This study tested the hypothesis that dopamine transporter (DAT) density in basal ganglia is a predictor of favorable methylphenidate (MP) treatment response. METHODS: 15 drug-naive boys with ADHD were included in this study (8 children: treatment responder, 7 children: treatment non responder). They were assessed with psychiatric interview, KEDI-WISC, K-ARS, ADS and CBCL. After then, they were performed [123 I]IPT SPECT. They were evaluated about treatment response after treatment with methylphenidate during 8 weeks. SPECT data reconstructed for the assessment of specific/nonspecific DAT binding ratio of the basal ganglia were compared between treatment responders and nonresponders. RESULTS: There were not significant differences in dopamine transporter density in basal ganglia between the two groups. CONCLUSION: This finding suggests that dopamine transporter density does not mediate the MP treatment response in a direct way.
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