Diabetes Metab J.  2012 Feb;36(1):56-63. 10.4093/dmj.2012.36.1.56.

The Association between Apolipoprotein A-II and Metabolic Syndrome in Korean Adults: A Comparison Study of Apolipoprotein A-I and Apolipoprotein B

• Yi DW
• Jeong DW
• Lee SY
• Son SM
• Kang YH

• KMID: 2281429
• DOI: http://doi.org/10.4093/dmj.2012.36.1.56

Abstract

BACKGROUND
Apolipoprotein A-II (apoA-II) is the second-most abundant apolipoprotein in human high-density lipoprotein and its role in cardio metabolic risk is not entirely clear. It has been suggested to have poor anti-atherogenic or even pro-atherogenic properties, but there are few studies on the possible role of apoA-II in Asian populations. The aim of this study is to evaluate the role of apoA-II in metabolic syndrome (MetS) compared with apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) in Korean adults.
METHODS
We analyzed data from 244 adults who visited the Center for Health Promotion in Pusan National University Yangsan Hospital for routine health examinations.
RESULTS
The mean apoB level was significantly higher, and the mean apoA-I level was significantly lower, in MetS; however, there was no significant difference in apoA-II levels (30.5+/-4.6 mg/dL vs. 31.2+/-4.6 mg/dL, P=0.261). ApoA-II levels were more positively correlated with apoA-I levels than apoB levels. ApoA-II levels were less negatively correlated with homocysteine and high sensitivity C-reactive protein levels than apoA-I levels. The differences in MetS prevalence from the lowest to highest quartile of apoA-II were not significant (9.0%, 5.7%, 4.9%, and 6.6%, P=0.279). The relative risk of the highest quartile of apoA-II compared with the lowest quartile also was not significantly different (odds ratio, 0.96; 95% confidence interval, 0.95 to 1.04; P=0.956).
CONCLUSION
Compared with apoA-I (negative association with MetS) and apoB (positive association with MetS) levels, apoA-II levels did not show any association with MetS in this study involving Korean adults. However, apoA-II may have both anti-atherogenic and pro-atherogenic properties.

Keyword

Apolipoprotein A-II; Cardio-metabolic risk; Metabolic syndrome

MeSH Terms

Adult
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins
Apolipoproteins B
Asian Continental Ancestry Group
C-Reactive Protein
Health Promotion
Homocysteine
Humans
Lipoproteins
Prevalence
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins
Apolipoproteins B
C-Reactive Protein
Homocysteine
Lipoproteins

Figure

• 

  Fig. 1 Prevalence of metabolic syndrome according to quartiles of ApoA-I, ApoA-II, and ApoB. Graphic bars are expressed as percent. Differences in prevalence among quartiles of each lipid marker were analysed using the chi-square test. ApoA-I, apolipoprotein A-I; ApoA-II, apolipoprotein A-II; ApoB, apolipoprotein B; 1, 1st quartile; 2, 2nd quartile; 3, 3rd quartile; 4, 4th quartile. aP<0.001; bP=0.007 compared to the 4th quartile.

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