Korean J Perinatol.
2008 Dec;19(4):351-355.
Change of cytokine expression in normal pregnancy and the puerperium
- Affiliations
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- 1Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. khmd.kim@samsung.com
Abstract
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PURPOSE: To investigate the serial relationship of cytokine production during normal pregnancy and in the puerperium.
METHODS
Plasma cytokine (TNF-alpha, INF-gamma, IL-2, TGF-beta, IL-4, and IL-6) levels were determined by enzyme-linked immunosorbent assay (ELISA) in 90 healthy gravidas during the second trimester and 6 weeks postpartum.
RESULTS
TNF-alpha, INF-gamma, and TGF-beta levels increased significantly after delivery (p<0.05). Although IL-2, IL-4, and IL-6 had a tendency to increase after delivery, the change was not significant.
CONCLUSION
There was a decrease in cytokine levels during pregnancy when compared to puerperium. In particular, TNF-alpha, INF-gamma, and TGF-beta were inversely related to the maintenance of normal pregnancy.
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