Korean J Orthod.  2014 Mar;44(2):96-102. 10.4041/kjod.2014.44.2.96.

The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations

• Yamaguchi
• Kawaguchi
• Kim YI
• Haga S
• Katayama K
• Ishida H
• Park SB
• Maki K
• Kimura R

• KMID: 2273432
• DOI: http://doi.org/10.4041/kjod.2014.44.2.96

Abstract

OBJECTIVE
A recent study suggested that rs6504340, a polymorphism within the homeobox B (HOXB) gene cluster, is associated with the susceptibility for malocclusions in Europeans. The resulting malocclusions require orthodontic treatment. The aim of this study was to investigate the association of rs6504340 and other dentition-implicated polymorphisms with dental and occlusal traits in Korean and Japanese populations.
METHODS
The study participants included 223 unrelated Koreans from the Busan area and 256 unrelated Japanese individuals from the Tokyo metropolitan area. DNA samples were extracted from saliva specimens. Genotyping for rs6504340 and four single nucleotide polymorphisms (SNPs) that have been shown to be associated with the timing of first tooth eruption and the number of teeth at 1 year of age (rs10506525, rs1956529, rs9674544, and rs8079702) was performed using TaqMan assays. The Index of Orthodontic Treatment Need (IOTN), overjet, overbite, arch length discrepancy, crown sizes, and length and width of the dental arches were measured. Spearman's correlation coefficients were calculated to evaluate relationships between rs6504340 and these dental/occlusal traits.
RESULTS
We evaluated the aesthetic components and dental health components of the IOTN in the Korean and Japanese populations and found that neither rs6504340 nor the other four SNPs showed any association with dental and occlusal traits in these East Asian populations.
CONCLUSIONS
These negative results suggest that further research is needed to identify the genetic determinants of malocclusions in order to reach a consensus.

Keyword

Genetics; Tooth size; Orthodontic index

MeSH Terms

Asian Continental Ancestry Group*
Busan
Consensus
Crowns
Dental Arch
DNA
Genes, Homeobox
Genetics
Humans
Index of Orthodontic Treatment Need
Malocclusion
Multigene Family
Overbite
Polymorphism, Single Nucleotide
Saliva
Tooth Eruption*
Tooth*
DNA

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