Korean J Obstet Gynecol.  2006 Dec;49(12):2612-2619.

A case of treatment of cervical adenocarcinoma associated with pregnancy by zinc-citrate compound (SeLava(R))

• Choi JH
• Lee YS
• Jung CK
• Park LO
• Bae SN

Abstract

Cervical carcinoma is the second leading cause of death from cancer in women worldwide. It is well known that human papillomaviruses (HPVs) is the etiologic agent of cervical neoplasia and cervical cancer. Zinc has been shown to inhibit the growth of malignant cell lines by inducing apoptosis and cell cycle arrest. Recently it was reported that zinc-citrate compound (CIZAR(R)) has a cytotoxic effect on choriocarcinoma cell line and ovarian adenocarcinoma cell line and suppresses its proliferation inducing apoptosis. CIZAR(R) prevents the proliferation by inactivation of m-aconitase activity and induces apoptosis by increasing Bax expression and reducing Bcl-2 expression and inactivation of telomerase. We report one patient of cervical adenocarcinoma with HPV infection, who desires to continue pregnancy, treated by daily topical application of SeLava(R) which contains zinc-citrate compound (CIZAR(R)). We followed up the cytologic, pathologic and coloposcopic changes of healing process.

Keyword

Cervical adenocarcinoma; Pregnancy; Zinc-citrate compound

MeSH Terms

Adenocarcinoma*
Apoptosis
Cause of Death
Cell Cycle Checkpoints
Cell Line
Choriocarcinoma
Female
Humans
Pregnancy*
Telomerase
Uterine Cervical Neoplasms
Zinc
Telomerase
Zinc