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Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Muneer A, Minhas FA

Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric...
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Matrix Production in Chondrocytes Transfected with Sex Determining Region Y-Box 9 and Telomerase Reverse Transcriptase Genes: An In Vitro Evaluation from Monolayer Culture to Three-Dimensional Culture

Noorhidayah MN, Zulkifly A, Khalid KA, Zainol I, Zamli Z, Sha'ban M

BACKGROUND: This study aimed to observe the cartilaginous matrix production in SRY (sex determining region Y)-box 9 (SOX9)- and/or telomerase reverse transcriptase (TERT)-transfected chondrocytes from monolayer to three-dimensional (3D) culture. METHODS:...
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Mouse Models as a Tool for Understanding Progression in Braf(V600E)-Driven Thyroid Cancers

Landa I, Knauf JA

The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have...
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Genomic Characterization of Differentiated Thyroid Carcinoma

Song YS, Park YJ

Since the release of The Cancer Genome Atlas study of papillary thyroid carcinoma (PTC) in 2014, additional genomic studies of differentiated thyroid carcinoma (DTC) using massively-parallel sequencing (MPS) have been...
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Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model

Shin PK, Zoh Y, Choi J, Kim MS, Kim Y, Choi SW

BACKGROUND/OBJECTIVES: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by hTERT and c-MYC, maintains telomeric DNA sequences. Especially, telomerase is...
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Relationship between Telomere Maintenance and Liver Disease

Barnard A, Moch A, Saab S

Previous studies have established a correlation between increasing chronological age and risk of cirrhosis. This pattern raised interest in the role of telomeres and the telomerase complex in the pathogenesis...
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Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity

Zhang S, Sun Y, Sui Y, Li Y, Luo Z, Xiao X, Zhou P, Wei S

BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the...
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Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis

Wang Z, Zhang Z, Guo Y, Shui H, Liu G, Jin T, Wang H

PURPOSE: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and...
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ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor

Lee JW, Park SH, Kang HJ, Park KD, Shin HY, Ahn HS

PURPOSE: In this study, anaplastic lymphoma kinase (ALK) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT)...
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Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development

Kim KC, Choi CS, Gonzales E, Mabunga DF, Lee SH, Jeon SJ, Hwangbo R, Hong M, Ryu JH, Han SH, Bahn GH, Shin CY

The valproic acid (VPA)-induced animal model is one of the most widely utilized environmental risk factor models of autism. Autism spectrum disorder (ASD) remains an insurmountable challenge among neurodevelopmental disorders...
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Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice

Kim KC, Cho KS, Yang SM, Gonzales E, Valencia S, Eun PH, Choi CS, Mabunga DF, Kim JW, Noh JK, Kim HJ, Jeon SJ, Han SH, Bahn GH, Shin CY

Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female...
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Evaluation of the Expression of the Inhibitor of Apoptosis Protein Family and Human Telomerase Reverse Transcriptase in Patients With Advanced Colorectal Adenoma

Choi JY, Yoon H, Na G, Choi YJ, Shin CM, Park YS, Kim N, Lee DH

BACKGROUND: It has been reported that the expression of the inhibitor of apoptosis protein (IAP) family increases in patients with colon cancer. We evaluated the expression of the IAP family...
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Molecular Testing of Brain Tumor

Park SH, Won J, Kim SI, Lee Y, Park CK, Kim SK, Choi SH

The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the...
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Longer Telomere Length of T lymphocytes in Patients with Early and Chronic Psychosis

Cui Y, Prabhu VV, Nguyen TB, Devi SM, Chung YC

OBJECTIVE: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5...
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Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome

Park HS, Choi J, See CJ, Kim JA, Park SN, Im K, Kim SM, Lee DS, Hwang SM

BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We...
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TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

Myung JK, Kwak BK, Lim JA, Lee MC, Kim MJ

PURPOSE: A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer. This TERT promoter mutation is thought to be a prognostic molecular marker, because its association with tumor...
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Improved development of somatic cell cloned bovine embryos by a mammary gland epithelia cells in vitro model

He XY, Ma LB, He XN, Si WT, Zheng YM

Previous studies have established a bovine mammary gland epithelia cells in vitro model by the adenovirus-mediated telomerase (hTERT-bMGEs). The present study was conducted to confirm whether hTERT-bMGEs were effective target...
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L-carnitine Effectively Induces hTERT Gene Expression of Human Adipose Tissue-derived Mesenchymal Stem Cells Obtained from the Aged Subjects

Farahzadi , Mesbah-Namin SA, Zarghami N, Fathi E

BACKGROUND AND OBJECTIVES: Human mesenchymal stem cells (hMSCs) are attractive candidates for cell therapy and regenerative medicine due to their multipotency and ready availability, but their application can be complicated...
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Evolution of Myelofibrosis Treatment

Eom KS

Myelofibrosis (MF) is a classical Philadelphia chromosome-negative myeloproliferative neoplasm characterized by clonal proliferation of pluripotent stem cells, dysfunctional kinase signaling, and abnormal cytokine release. MF is a heterogeneous disease, ranging...
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Low Prevalence of Somatic TERT Promoter Mutations in Classic Papillary Thyroid Carcinoma

Jeon MJ, Kim WG, Sim S, Lim S, Kwon H, Kim TY, Shong YK, Kim WB

BACKGROUND: Transcriptional activating mutations of telomerase reverse transcriptase (TERT) are associated with more aggressive thyroid cancer. We evaluated the significance of TERT promoter mutations in Korean patients with classic papillary...
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