Korean J Obstet Gynecol.  2003 Nov;46(11):2156-2161.

Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease

• Chung IB
• Cha DS
• Sohn JH
• Choi SJ
• Han KH

Abstract

Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism.
OBJECTIVE
To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua.
METHODS
we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization.
RESULTS
All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2).
CONCLUSION
we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed.

Keyword

Apoptosis; Feto-maternal interface; TRAIL (Apo-2L)/TRAIL receptor system

MeSH Terms

Apoptosis*
Decidua
Female
Fertilization
Gestational Trophoblastic Disease*
Humans*
Placenta
Pregnancy
Receptors, TNF-Related Apoptosis-Inducing Ligand
Uterus
Receptors, TNF-Related Apoptosis-Inducing Ligand