Korean J Obes.  2012 Mar;21(1):45-56.

Comparisons of Body Composition and 12 Week Combined Exercise Intervention-mediated Effects According to ACE and IGF-1 Gene Polymorphisms in Children

  • 1Department of Physical Education, Keimyung University, Korea. kjk744@kmu.ac.kr


The purpose of this study was to analyze the genetic effects through interaction of ACE gene and IGF-1 polymorphism on the anthropometric measurements of the subjects. The effects of a 12 week combined exercise program were also investigated to provide better methods for preventing and managing childhood obesity.
Subjects comprised of 179 (111 boys; 68 girls) 4th grade elementary school students who participated in a 12 week exercise program involving 3 sessions/week of both aerobic and anaerobic exercise. The students were categorized into 9 different groups according to IGF-1 and ACE gene polymorphism. Height, weight, body mass index (BMI), body fat percent (%fat), lean body mass (LBM), body circumference and skinfold thickness were measured. The effects after the 12 week exercise program were analyzed among the different groups.
The BMI of Non-DD group were significantly (P < 0.05) higher than Non-ID group, the %fat and fat mass of Non-II group were significantly (P < 0.05) higher than 192/192-ID, 192/Non-DD and Non-ID groups. After the exercise program, the weight of 192/Non-II, 192/Non-ID and 192/Non-DD group were significantly (P < 0.05) increased compared to Non-II and Non-ID group. The BMI of Non-ID group were significantly (P < 0.05) decreased than 192/Non-ID group. The %fat of 192/192-II and Non-DD group were significantly (P < 0.05) decreased than 192/Non-ID group. The %fat of 192/192-II and Non-DD group were significantly (P < 0.05) decreased than 192/Non-DD group. The fat mass of 192/192-II group were significantly (P < 0.05) decreased compared to 192/Non-DD group.
The body composition was probably affected by ACE rather than IGF-1 polymorphism. D allele of ACE gene is postulated to manifest lower body fat % compared to I allele. The exercise effects on body composition was more effective in I allele of 192/192 group and in D allele of Non carriers group. Exercise-mediated change on body composition may differ according to ACE gene polymorphism.


ACE; IGF-1; Gene polymorphism; Body composition; Exercise training

MeSH Terms

Adipose Tissue
Body Composition
Body Weight
Insulin-Like Growth Factor I
Skinfold Thickness
Insulin-Like Growth Factor I
Full Text Links
  • KJO
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr