Korean J Nutr.  2010 Jun;43(3):315-323. 10.4163/kjn.2010.43.3.315.

Vitamin B6 Requirement: Indicators and Factors Affecting

Affiliations
  • 1Department of Food and Nutrition, Ducksung Women's University, Seoul 132-714, Korea. yunokcho@duksung.ac.kr

Abstract

The purpose of this study was to establish the selection of indicators for estimating and factors affecting the requirement of vitamin B6. There has been a need to establish the human requirements of vitamin B6 since vitamin B6 is thought to be involved in more than one hundred biochemical reactions as a coenzyme in the metabolism of amino acids, glucose, and lipid, and the synthesis of neurotransmitters. For the review of the literature, this study included from early findings of the sixties to studies of 2009. This study suggests that plasma pyridoxal 5' phosphate (PLP) is the best single indicator of vitamin B6 status for the healthy but not for the non-healthy. Erythrocyte aspartate aminotransferase and alanine aminotransferase activation by PLP as an indirect measure and urinary 4-pyridoxic acid excretion as a direct measure are useful as supporting indicators. Bioavailability, nutrient interaction, physiological need, and chronic diseases may increase the requirement for vitamin B6. However, these effects can not be quantified due to insufficient evidences.

Keyword

vitamin B6 requirement; vitamin B6 status; vitamin B6 indicator; vitamin B6 DRI

MeSH Terms

Alanine Transaminase
Amino Acids
Aspartate Aminotransferases
Biological Availability
Chronic Disease
Erythrocytes
Glucose
Humans
Neurotransmitter Agents
Plasma
Pyridoxal
Pyridoxic Acid
Vitamin B 6
Vitamins
Alanine Transaminase
Amino Acids
Aspartate Aminotransferases
Glucose
Neurotransmitter Agents
Pyridoxal
Pyridoxic Acid
Vitamin B 6
Vitamins

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