Ann Rehabil Med.  2012 Jun;36(3):340-346. 10.5535/arm.2012.36.3.340.

Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders

Affiliations
  • 1Department of Rehabilitation Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea. sylee@dsmc.or.kr
  • 2Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea.
  • 3Department of Otolaryngology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea.

Abstract


OBJECTIVE
To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires. METHOD: A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance.
RESULTS
DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.
CONCLUSION
Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.

Keyword

Sialorrhea; Botulinum toxin; Salivary gland; Children; Neurologic disorder

MeSH Terms

Botulinum Toxins
Botulinum Toxins, Type A
Child
Follow-Up Studies
Humans
Nervous System Diseases
Parotid Gland
Salivary Glands
Sialorrhea
Sorbitol
Tyramine
Botulinum Toxins
Botulinum Toxins, Type A
Sorbitol
Tyramine

Figure

  • Fig. 1 Changes of the mean scores of drooling measurements for 9 months (n=6, one patient was excluded due to a percutaneous endoscopic gastrostomy).


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