Korean J Obstet Gynecol.
2002 Jan;45(1):78-83.
When Can We Identify Fetal Male Gene By Using Maternal Plasma DNA?
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Korea University, Korea.
- 2Graduate School of Biotechnology, Korea University, Korea.
Abstract
OBJECTIVE
To know when we can identify fetal Y chromosome SRY gene by using fetal DNA in maternal plasma.
METHODS
DNA from maternal plasma of 62 pregnant women (48: inpatients, 14: outpatients) underwent a sensitive Y-PCR assay to identify SRY gene of Y chromosome.
RESULTS
Of the patients, fetus-derived Y sequences were detected in 37 (88.1%) of the 42 maternal plasma samples from women bearing male fetuses. One of the 20 women bearing female fetuses had positive result from plasma DNA. Seventh gestational week was the earliest gestation of gender identification.
CONCLUSION
We could identify fetal gender using fetal DNA in maternal plasma (sensitivity 88.1%). The earlist to detect was 7th gestational week.
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