Korean J Med.  2011 Jun;80(Suppl 2):S301-S304.

Yellow Fever Vaccine-associated Viscerotropic Disease

Affiliations
  • 1Department of Infectious Disease, Keimyung University School of Medicine, Daegue, Korea. 121rsy@dsmc.or.kr
  • 2Division of Arboviruses, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Korea.
  • 3Department of Infectious Disease, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

This report describes a case of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) that occurred after vaccination in a 23-year-old male. Seven days after vaccination, our patient presented with fever, myalgia, and nausea. The IgM enzyme-linked immunosorbent assay (ELISA) for yellow fever virus was positive. After a 24 day hospitalization, he recovered and was discharged. Yellow fever is a viral hemorrhagic febrile illness caused by a flavivirus and transmitted by mosquitoes. The clinical presentation ranges from a mild febrile illness to a serious infection, leading to hepatic and renal failure, myocardial injury, hemorrhage, and shock, with a case fatality rate of 20-30%. Because yellow fever is a potentially fatal disease, vaccination is encouraged for people traveling to high-risk areas. Although considered a safe vaccine, severe adverse reactions have been reported. In 2001, rare, but severe, acute viscerotropic disease following vaccination was first described. We report the case of a 23-year-old male with fever and hepatitis following vaccination with 17D yellow fever vaccine.

Keyword

Yellow fever; Hepatitis; Vaccination

MeSH Terms

Culicidae
Enzyme-Linked Immunosorbent Assay
Fever
Flavivirus
Hemorrhage
Hepatitis
Hospitalization
Humans
Immunoglobulin M
Male
Nausea
Renal Insufficiency
Shock
Vaccination
Yellow Fever
Yellow Fever Vaccine
Yellow fever virus
Young Adult
Immunoglobulin M
Yellow Fever Vaccine
Full Text Links
  • KJM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr