Korean J Nephrol.
2005 May;24(3):470-474.
A Case of Carbamazepine-induced Acute Interstitial Nephritis
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea. sjwdr@hanmail.net
- 2Department of Neurosurgery, College of Medicine, Hallym University, Seoul, Korea.
- 3Department of Pathology, College of Medicine, Hallym University, Seoul, Korea.
Abstract
- We report a case of acute interstitial nephritis associated with carbamazepine in a 45-year-old woman who developed acute renal failure. The patient has been taken valproic acid and carbamazepine to control the recurrent episodes of seizure after the surgery for meningioma. The patient developed acute renal failure with fever and skin rash. The patient stopped all medications except valproic acid, and was examined by ultrasonography, gallium scan and renal biopsy. Renal biopsy revealed severe interstitial infiltration of neutrophils in glomeruli without inflammation. After discontinuation of carbamazepine, acute renal failure of the patient improved and serum creatinine returned to normal.
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