J Korean Acad Rehabil Med.  2002 Aug;26(4):489-491.

Carbamazepine-induced Acute Interstitial Lung Disease

• Kim K
• kang MJ
• Kim KT
• Lee JS

Abstract

Seven days after starting carbamazepine therapy because of a central pain, a 67-year old man with the occlusion of left middle cerebral artery developed acute interstitial lung disease with severe dyspnea and decreased consciousness. Initial therapy included mechanical ventilation, discontinuation of carbamazepine, and injection with epinephrine and steroid. Five days after developing the acute interstitial lung disease, his clinical status and the finding of simple chest X-ray were markedly improved. Several days later, there was the removal of the ventilator and resolution of pulmonary symptoms. Acute interstitial lung disease is a rare fatal adverse reaction to carbamazepine therapy. However, awareness of carbamazepine-induced lung disease may reduce delays in both diagnosis and withdrawal of the drug.

Keyword

Carbamazepine; Acute interstitial lung disease

MeSH Terms

Aged
Carbamazepine
Consciousness
Diagnosis
Dyspnea
Epinephrine
Humans
Lung Diseases
Lung Diseases, Interstitial*
Middle Cerebral Artery
Respiration, Artificial
Thorax
Ventilators, Mechanical
Carbamazepine
Epinephrine