Korean J Nephrol.  2008 Jul;27(4):513-517.

Selective Proximal Tubule Injury and Progressive Renal Failure due to Ifosfamide and Cisplatin in a Patient with Ovarian Cancer

• Kim SH
• Nam SM
• Yoon HE
• Kim YK
• Park EY
• Kim WY
• Kim YS

Abstract

Ifosfamide-induced nephrotoxicity is usually manifested in the form of Fanconi syndrome and the combination of cisplatin enhances ifosfamide-induced nephrotoxicity. We here report a case of report specific proximal tubular dysfunction and progressive renal failure after ifosfamide and cisplatin chemotherapy in a 32-year old woman with ovarian cancer. The patient was referred to our department due to severe hypokalemia and elevated serum creatinine. Her renal function was abruptly impaired and serum and urine electrolytes were consistent with Fanconi syndrome. The kidney biopsy revealed atrophy and falling of renal tubular cells, and immunohistochemical staining with aquaporin 1 (AQP1) revealed that injured epithelial cells were proximal tubular cells. This finding suggests that ifosfamide selectively impairs proximal tubule function and combination with cisplatin causes progressive renal failure

Keyword

Ifosfamide; Fanconi syndrome; Renal failure

MeSH Terms

Aquaporin 1
Atrophy
Biopsy
Cisplatin
Creatinine
Electrolytes
Epithelial Cells
Fanconi Syndrome
Female
Humans
Hypokalemia
Ifosfamide
Kidney
Ovarian Neoplasms
Renal Insufficiency
Aquaporin 1
Cisplatin
Creatinine
Electrolytes
Ifosfamide