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Proximal renal tubular acidosis with and without Fanconi syndrome

Kashoor I, Batlle D

Proximal renal tubular acidosis (RTA) is caused by a defect in bicarbonate (HCO₃⁻) reabsorption in the kidney proximal convoluted tubule. It usually manifests as normal anion-gap metabolic acidosis due to...
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Acute Tubular Necrosis associated with the Ketogenic Diet in a Child with Intractable Epilepsy

Yoo KH, Yim HE

The ketogenic diet (KD) has been used as an effective antiepileptic therapy for intractable childhood epilepsy. However, various adverse effects have been reported with use of the KD. We report...
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Tenofovir-induced renal tubular dysfunction among human immunodeficiency virus patients on antiretroviral therapy in Nigeria: Prospects for early detection of presymptomatic nephrotoxicity

Obiebi IP, Nwannadi E

BACKGROUND: Tenofovir disoproxil fumarate (TDF) is relatively safe, although renal toxicity has been reported. In Nigeria, there is insufficient data on renal toxicity among patients on TDF. This study assesses...
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Adefovir-induced Fanconi syndrome associated with osteomalacia

Park S, Kim WI, Cho DH, Kim YJ, Kim HS, Kim JH, Cha SK, Park KS, Lee JH, Lee SM, Lee EY

Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome...
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Update of aristolochic acid nephropathy in Korea

Ban TH, Min JW, Seo C, Kim DR, Lee YH, Chung BH, Jeong KH, Lee JW, Kim BS, Lee SH, Choi BS, Han JS, Yang CW

BACKGROUND/AIMS: The true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected to contain aristolochic acid (AA) are used in traditional medicine...
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Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy

Yi JH, Han SW, Kim WY, Kim J, Park MH

BACKGROUND/AIMS: This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN). METHODS: After an adaptation period (1 week), a total...
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An Uncommon Case of Bilateral Pathologic Hip Fractures: Antiviral Drug-induced Osteomalacia in a Patient with Hepatitis B

Moon NH, Shin WC, Do MU, Cho HJ, Suh KT

The long-term use of adefovir and tenofovir–antiviral medications commonly used to treat chronic hepatitis B–can be associated with proximal renal tubular dysfunction resulting in significant hypophosphatemic osteomalacia. However, there have...
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Adult Idiopathic Renal Fanconi Syndrome: A Case Report

Park DJ, Jang KS, Kim GH

Renal Fanconi syndrome (RFS) is caused by generalized proximal tubular dysfunction and can be divided into hereditary and acquired form. Adult-onset RFS is usually associated with drug toxicity or systemic...
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Renal Tubular Acidosis in Patients with Primary Sjögren's Syndrome

Jung SW, Park EJ, Kim JS, Lee TW, Ihm CG, Lee SH, Moon JY, Kim YG, Jeong KH

Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial...
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Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B

Lee YS, Kim BK, Lee HJ, Dan J

In Fanconi syndrome, hypophosphatemic osteomalacia is caused by proximal renal tubule dysfunction which leads to impaired reabsorption of amino acids, glucose, urate, and phosphate. We present a rare case of...
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A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

Kim D, Lee J, Kim DH, Kang K, Suh SJ, Jung YK, Yim HJ

Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity...
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Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma

Lee EJ, Lee SY, Park SY, Kim Y, Choi JS, Kim MJ, Park JH, Lee JE, Kwon GY, Kim YG

Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause...
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Fanconi Syndrome Associated with Long-term Adefovir and Subsequent Tenofovir Therapy for Chronic Hepatitis B Infection

Lee HW, Lee JS, Oh SW, Jung JH, Park MY, Kim KA, Song YH

Adefovir dipivoxil (ADV) and tenofovir disoproxil fumarate (TDF) are nucleotide analogues used to treat chronic hepatitis B (CHB) infection. Nephrotoxicity associated with the use of these medications causes Fanconi syndrome,...
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A Case of Tubulointerstitial Nephritis and Uveitis with Fanconi Syndrome

Kim M, Kim HW, Kim JY, Jeong J, Park EJ, Kim J, Kim SM

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease that comprises 4.7% of acute interstitial nephritis. With reno-ocular manifestations, TINU syndrome is accompanied by symptoms such as fever, fatigue,...
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A case of Fanconi syndrome accompanied by crystal depositions in tubular cells in a patient with multiple myeloma

Kim DH, Lim AY, Gwag HB, Lee JH, Jung KS, Lee K, Huh W, Kim DJ, Kim YG, Oh HY, Kim K, Kwon GY, Lee JE

  • KMID: 2224277
  • Kidney Res Clin Pract.
  • 2014 Jun;33(2):112-115.
Fanconi syndrome (FS) is a rare condition that is characterized by defects in the proximal tubular function. A 48-year-old woman was admitted for evaluation of proteinuria. The patient showed normal...
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Ifosfamide-induced Fanconi syndrome with diabetes insipidus

Leem AY, Kim HS, Yoo BW, Kang BD, Kim MH, Rha SY, Kim HS

Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40-60 g/m2, a reduction in kidney mass, or concurrent...
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Lowe syndrome: a single center's experience in Korea

Kim HK, Kim JH, Kim YM, Kim GH, Lee BH, Choi JH, Yoo HW

PURPOSE: Lowe syndrome is a rare, X-linked recessive disorder caused by mutations in the OCRL gene. It involves multiple anatomic systems, particularly the eyes, central nervous system, and kidneys, and...
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Two Cases of Hypophosphatemic Osteomalacia After Long-term Low Dose Adefovir Therapy in Chronic Hepatitis B and Literature Review

Jeong HJ, Lee JM, Lee TH, Lee JY, Kim HB, Heo MH, Choi G, Chae JN, Kim JM, Kim SH, Kwon KY

  • KMID: 2391956
  • J Bone Metab.
  • 2014 Feb;21(1):76-83.
Adefovir dipivoxil (ADV) is a nucleotide used as long-term therapy of chronic hepatitis B. Many published reports have shown that long-term high-dose therapy with adefovir can be associated with proximal...
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A Case of Fanconi-Bickel Syndrome with Mild Clinical Signs

Kim SM, Yoo HW, Kim HW

  • KMID: 2267816
  • Korean J Med.
  • 2013 Aug;85(2):210-213.
Fanconi-Bickel syndrome is a rare autosomal recessive disorder caused by a mutation in the facilitative glucose transporter 2 gene (GLUT2 or SLC2A2 gene) that codes for the glucose transporter protein...
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Fanconi's Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient

Jung YK, Yeon JE, Choi JH, Kim CH, Jung ES, Kim JH, Park JJ, Kim JS, Bak YT, Byun KS

  • KMID: 1974143
  • Gut Liver.
  • 2010 Sep;4(3):389-393.
Adefovir dipivoxil (ADV) is commonly used as an antiviral agent in the treatment of chronic hepatitis B or human immunodeficiency virus infection. Nephrotoxicity has been shown to occur at daily...
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