Korean J Med.  2003 May;64(5):597-602.

A case of amyloidosis associated with early gastric cancer

• Kim HM
• Jung IH
• Han SH
• Chin BS
• Lee HY
• Noh SH
• Yang WI

Abstract

The amyloidosis combined with malignant neoplasm, especially stomach cancer, is rare. We experienced a case of a 60 year-old male patient who had complained of facial and lower leg edema. The laboratory findings were consistent with nephrotic syndrome, and CEA was slightly elevated. Gastroduodenoscopy revealed early gastric cancer, which suggested that the nephrotic syndrome should be associated with neoplasm, an example of membranous glomerulonephritis. Wedge resection of stomach was done with incidental splenectomy and liver biopsy. Following microscopic examination, amyloidosis was found to be involved in the liver and spleen. Bone marrow biopsy did not show any evidence of plasma cell dyscrasia. According to the literature, neoplasm can stimulate the production or precipitation of serum amyloid A like chronic infection and inflammation. But we cannot conclude that stomach neoplasm caused secondary amyloidosis, such as renal cell carcinoma or Hodgkin disease, regarding as the possibility of coincidental amyloidosis. We report a case of amyloidosis associated with early gastric cancer, represented by nephrotic syndrome.

Keyword

Amyloidosis; Nephrotic syndrome; Stomach neoplasm

MeSH Terms

Amyloidosis*
Biopsy
Bone Marrow
Carcinoma, Renal Cell
Edema
Glomerulonephritis, Membranous
Hodgkin Disease
Humans
Inflammation
Leg
Liver
Male
Middle Aged
Nephrotic Syndrome
Paraproteinemias
Serum Amyloid A Protein
Spleen
Splenectomy
Stomach
Stomach Neoplasms*
Serum Amyloid A Protein