Korean J Nephrol.  1998 Mar;17(2):335-339.

A Case of Membranous Nephropathy Associated with Early Gastric Cancer

• Kim YW
• Hwang HS
• Kim YH
• Yoon HK

Abstract

The nephrotic syndrome complicating malignancy in the absence of amyloidosis, renal vein thromosis or neoplastic infiltration of kidney is a rare disease. The nephrotic syndrome has been reported in association with a wide variety of neoplastic disease, but it has only rarely been noted as a complication of early gastric cancer. We describe a patient who presented with the nephrotic syndrome and was subsequently found to have early gastric cancer. The findings on renal biopsy were indicative of membranous nephropathy by light, immunofluorescence and electron microscopy. Endoscopic biopy on stomach demonstrated the signet ring cell carcinoma by light microscopy. Successful treatment of early gastric cancer did not completely resolve the nephrotic syndrome but led to significant redution of proteinuria and improved edema. We reported a patient who presented with membranous nephropathy combined with early gastric cancer.

Keyword

Early gastric cancer; Membranous nephropathy

MeSH Terms

Amyloidosis
Biopsy
Carcinoma, Signet Ring Cell
Edema
Fluorescent Antibody Technique
Glomerulonephritis, Membranous*
Humans
Kidney
Microscopy
Microscopy, Electron
Nephrotic Syndrome
Proteinuria
Rare Diseases
Renal Veins
Stomach
Stomach Neoplasms*