Korean J Hematol.  2005 Mar;40(1):41-44. 10.5045/kjh.2005.40.1.41.

A Case of Coexistent Chronic Lymphocytic Leukemia and Multiple Myeloma

• Nam SH
• Kwon JM
• Mun YC
• Lee KE
• Lee SY
• Chung WS
• Lee SN
• Seong CM

• KMID: 2252365
• DOI: http://doi.org/10.5045/kjh.2005.40.1.41

Abstract

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are both lymphoproliferative disease occurring in different stages of B cell oncogeny. An increased incidence of secondary malignancies in patients with CLL is well recognized, however, the coexistence of both disorders in the same patient was very rare. Furthermore, clonal relationship between these diseases has not been clearly established. We report the occurrence of MM during the course of CLL. A 68-year-old patient was presented with general weakness and bone marrow aspiration showed a hypercellular marrow with 80% mature lymphocytes. At 5 months after diagnosis of CLL, bone marrow of the patient showed increased immature plasma cells. Serum protein electrophoresis showed monoclonal gammopathy and serum immunoelectrophoresis IgG kappa type monoclonality. The patient received six cycles of VAD (vincristine, adriamycin, dexamethasone) chemotherapy, but died of pneumonia and sepsis.

Keyword

Coexistence; Chronic lymphocytic leukemia; Multiple myeloma

MeSH Terms

Aged
Bone Marrow
Diagnosis
Doxorubicin
Drug Therapy
Electrophoresis
Humans
Immunoelectrophoresis
Immunoglobulin G
Incidence
Leukemia, Lymphocytic, Chronic, B-Cell*
Lymphocytes
Multiple Myeloma*
Paraproteinemias
Plasma Cells
Pneumonia
Sepsis
Doxorubicin
Immunoglobulin G

Figure

• 

  Fig. 1. Initial bone marrow aspiration shows mature-appearing, small lymphocytes (Wright-Giemsa stain, ×400).

• 

  Fig. 2. Bone marrow aspiration shows immature plasma cells with round or oval shape at 5 months after initial diagnosis (Wright-Giemsa stain, ×1,000).

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