Korean J Hematol.  2009 Sep;44(3):168-171. 10.5045/kjh.2009.44.3.168.

A Case of Hantavirus Pulmonary Syndrome Mimicking Apalastic Anemia with Invasive Aspergillosis

• Yoo KD
• Park SH
• Kim DM
• Seo JY
• Lee HR
• Yuh YJ
• Kim SR
• Shin E
• Yoo SJ

• KMID: 2252137
• DOI: http://doi.org/10.5045/kjh.2009.44.3.168

Abstract

Hantavirus is known to a causative agent of hemorrhagic fever with renal syndrome and it can cause hantavirus pulmonary syndrome, a rare disease in Korea. Hantavirus pulmonary syndrome is usually associated with pulmonary hemorrhage and fever. The common hematologic features of this syndrome are elevated hematocrit level, leukocytosis and thrombocytopenia. We report a case of hantavirus pulmonary syndrome with pancytopenia. This patient with severe neutropenia with pulmonary infiltration mimicked aplastic anemia with invasive aspergillosis.

Keyword

Hantavirus pulmonary syndrome; Pancytopenia; Hantavirus

MeSH Terms

Anemia
Anemia, Aplastic
Aspergillosis
Fever
Hantavirus
Hantavirus Pulmonary Syndrome
Hematocrit
Hemorrhage
Hemorrhagic Fever with Renal Syndrome
Humans
Korea
Leukocytosis
Neutropenia
Pancytopenia
Rare Diseases
Thrombocytopenia

Figure

• 

  Fig. 1. A newly developed pulmonary right upper lobe infiltration was observed in chest X-ray taken at admission 6th day. (A: chest X-ray taken at admission 2nd day, B: chest X-ray taken at admission 6th day).

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  Fig. 2. The feature of bone marrow biopsy was compatible with aplastic anemia with cellularity less than 5%.

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  Fig. 3. Pulmonary right upper lobe infiltration was observed in chest CT.

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  Fig. 4. Core needle biopsy of involved lung field showed alveolar hemorrhage without evidence of hyphae (A: ×40, B: ×100).

Reference

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