Korean J Gastrointest Endosc.  2005 Sep;31(3):180-184.

A Case of Cap Polyposis Successfully Managed with Infliximab

  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ytjeen@korea.ac.kr
  • 2Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea.
  • 3Department of Pathology, Korea University College of Medicine, Seoul, Korea.


Cap polyposis is a rare disorder characterized by bloody, mucoid diarrhea with rectosigmoid polyps covered by a cap of fibrinopurulent exudate. The etiology and pathogenesis of cap polyposis is unknown, and no specific treatment has been established. Drug therapies are usually unsuccessful. Patients with a solitary cap polyp respond well to endoscopic polypectomy, while patients with multiple polyps and concurrent anorectal pathology require surgical resection. However, rapid recurrence has been described after a limited surgical resection, and this necessitates panproctocolectomy. We report a case of a 58-year-old female diagnosed as cap polyposis on rectum with similar clinical and endoscopic features of pseudomenbranous colitis successfully treated with infliximab (murine chimeric monoclonal antibody to TNF-alpha).


Cap polyposis; Infliximab; Pseudomembranous colitis
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