Korean J Anesthesiol.  1999 Sep;37(3):382-386. 10.4097/kjae.1999.37.3.382.

The Effect of Pretreated Intravenous Lidocaine on Hypnotic Effect and Requirement of Propofol during Anesthesia Induction

• Chung MY
• Jeong DS
• Joo JD
• Kim CJ
• Chae JS
• Lee BH

• KMID: 2240035
• DOI: http://doi.org/10.4097/kjae.1999.37.3.382

Abstract

BACKGROUND: Recently, it was reported that bupivacaine-induced spinal block significantly reduced the hypnotic requirements for thiopentone, midazolam and propofol. We evaluated the hypnotic effect and requirements for intravenous propofol when pretreated with intravenous lidocaine.
METHODS
Fifty patients, ASA I or II, undergoing minor surgical procedures were randomly divided into five groups according to anesthetic pretreatment (group N: 0.9% normal saline; group 0.5: lidocaine 0.5 mg/kg; group 1.0: lidocaine 1.0 mg/kg; group 1.5: lidocaine 1.5 mg/kg; group 2.0 lidocaine 2.0 mg/kg). Ninty seconds after the administration of normal saline or lidocaine, propofol was administered intravenously over 5 sec in bolus doses of 0.2 mg/kg every 30 sec. The inability of patients respond to a simple command ("Open your eyes," said twice) was used as the end point for hypnosis. Responses to verbal commands were evaluated 25 sec after each bolus. The total dose required to achieve complete loss of response in each patient was recorded in mg/kg. The time of the loss of response was from the adminstration of propofol to the loss of response. Mean arterial pressures and heart rates were measured before induction, after loss of response, and immediately after induction.
RESULTS
The time and total dose required to achieve loss of response was significantly reduced in groups 1.0, 1.5 and 2.0. Heart rates in groups 2.0 and mean arterial pressure in groups 0.5, 1.0, 1.5, 2.0 were significantly decreased after the loss of response.
CONCLUSIONS
We suggest that lidocaine pretreatment significantly enhances the hypnotic effect and reduces the dose requirement for propofol during the induction period.

Keyword

Anesthetics, intravenous, propofol; Anesthetics, local, lidocaine

MeSH Terms

Anesthesia*
Arterial Pressure
Heart Rate
Humans
Hypnosis
Hypnotics and Sedatives*
Lidocaine*
Midazolam
Propofol*
Surgical Procedures, Minor
Thiopental
Hypnotics and Sedatives
Lidocaine
Midazolam
Propofol
Thiopental