Korean J Anesthesiol.  1987 Aug;20(4):470-476. 10.4097/kjae.1987.20.4.470.

Neuromuscular Elock by Vecuronium and Neostigmine Effect in Hypothermic Rabbits

• Kim HS
• Lee DH
• Kim KH
• Kim KS
• Suh JK
• Yoo HK
• Seung IS
• Chon SU

• KMID: 2239515
• DOI: http://doi.org/10.4097/kjae.1987.20.4.470

Abstract

Anesthesiologists may have close relationship with muscle relaxants in clinioal practice. Fortunately, few of the new muscle relaxants were discovered and used in clinic recently. And also hypothermia reduced the effectiveness and prolonged duration of non-depolarizing b1ock, has been challenged, and it is now generally accepted that hypothermia prolongs the duration of non-depolarizing neuromuscular block. But exactly how much b1ock mar prolonged is not mentioned so there may exist controversial result from animal to animal. We have studied newly introduced vecuronium effects during hypothermic rabbits. The results were as follows ; 1. Spontaneous recovery index by vecuronium 7.05 mg/kg in normothermic rabbit was 216.4 sec(3.6 min). 2. Spontaneous recovery index by vecuronium 0.05 mg/kg in hypothermic (32degrees C) rabbit was markedly prolonged as 441.3 sec(7.35 min) . 3. Recovery index by the neostigmine 40 ug/kg reversal in hypothermic(32degrees C) rabbit was 120.1 sec(2.0min). Authors concluded that vecuronium effects on hypothermic rabbits were markedly prolo- nged and promptly reversed.

MeSH Terms

Animals
Hypothermia
Neostigmine*
Neuromuscular Blockade
Rabbits*
Vecuronium Bromide*
Neostigmine
Vecuronium Bromide