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Current use of neuromuscular blocking agents and antagonists in Korea: a 2018 survey

Kim JS, Han JW, Lee JH, Choi JM, Kim HJ, Sung TY, Kim YB, Shin YS, Yang HS

BACKGROUND: Neuromuscular blocking agents (NMBAs) and neuromuscular monitoring in anesthetic management are integral for endotracheal intubation, better visualization of the surgical field, and prevention of residual neuromuscular blockade and pulmonary...
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Ogilvie's Syndrome after Lumbar Spinal Surgery

Lee SK, Lee SH, Park BM, Yang BS, Kim JH, Lee HM

STUDY DESIGN: Case report. OBJECTIVES: We report a case of Ogilvie's syndrome following posterior decompression surgery in a spinal stenosis patient who presented with acute abdominal distension, nausea, and vomiting. SUMMARY OF...
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Initial experience with the unrestricted introduction of sugammadex at a large academic medical center: a retrospective observational study examining postoperative mechanical ventilation and efficiency outcomes

O'Reilly-Shah VN, Lynde GC, Mitchell M, Maffeo CL, Jabaley CS, Wolf FA

BACKGROUND: Sugammadex rapidly reverses deep neuromuscular blockade, but owing to cost, questions remain about its optimal utilization. After the unrestricted introduction of sugammadex at Emory University Hospital, we hypothesized that...
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Comparison of Sugammadex and Neostigmine on First Spontaneous Breathing and Adverse Effects for Laparoscopic Cholecystectomy

Park H, Park MS, Kim MJ, Kim KS, Cho YS, Bae SS, Rhie SJ

OBJECTIVE: The purpose of the study was to investigate the time from the injection of muscle relaxants to the first spontaneous respiration between sugammadex and conventional reversal for patients undergoing...
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Neostigmine Treatment of Paralytic Ileus in Critically Ill Patients

Choi NJ, Kim TH, Hong SK

Paralytic ileus is a common complication in critically ill patients, and can affect all parts of the gastrointestinal tract. We report a case of paralytic ileus that improved after neostigmine...
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Intravenous Neostigmine Test for Diagnosis of Ocular Myasthenia Gravis

Kim DI, Lee BJ, Kim SJ

PURPOSE: In the present study, we evaluated the validity of intravenous neostigmine administration combined with alternate prism cover test (APCT) measurement as a confirmatory diagnostic method for confusing cases of...
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Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit

Park SY, Burton D, Busciglio , Eckert D, Camilleri

  • KMID: 2367460
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):92-100.
  • doi: 10.5056/jnm16066
BACKGROUND/AIMS: After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference...
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Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors

Lee HE, Kim YH, Kim SM, Shin HY

BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small...
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Relationship between first-twitch depression and train-of-four ratio during sugammadex reversal of rocuronium-induced neuromuscular blockade

Kim KS, Oh YN, Kim TY, Oh SY, Sin YH

BACKGROUND: The primary outcome of sugammadex reversal for rocuronium-induced neuromuscular block (NMB) is a train-of-four ratio (TOFR) of 0.9, not first twitch (T1) height. We investigated whether the recovery of...
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Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery

Pyo JH, Min YW, Rhee PL

Neostigmine can successfully decompress patients with acute colonic pseudo-obstruction (ACPO) who are unresponsive to conservative therapy. However, neostigmine is contraindicated in renal failure, so it is underused in ACPO patients...
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The combination of sugammadex and neostigmine can reduce the dosage of sugammadex during recovery from the moderate neuromuscular blockade

Cheong SH, Ki S, Lee J, Lee JH, Kim MH, Hur D, Cho K, Lim SH, Lee KM, Kim YJ, Lee W

BACKGROUND: Sugammadex is a novel neuromuscular reversal agent, but its associated hypersensitivity reaction and high cost have been obstacles to its widespread use. In the interest of reducing the necessary...
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Regulation of Gastric Electrical and Mechanical Activity by Cholinesterases in Mice

Worth AA, Forrest AS, Peri LE, Ward SM, Hennig GW, Sanders KM

  • KMID: 2381252
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):200-216.
  • doi: 10.5056/jnm14120
BACKGROUND/AIMS: Gastric peristalsis begins in the orad corpus and propagates to the pylorus. Directionality of peristalsis depends upon orderly generation and propagation of electrical slow waves and a frequency gradient...
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Clinical and Electrophysiologic Responses to Acetylcholinesterase Inhibitors in MuSK-Antibody-Positive Myasthenia Gravis: Evidence for Cholinergic Neuromuscular Hyperactivity

Shin HY, Park HJ, Lee HE, Choi YC, Kim SM

BACKGROUND AND PURPOSE: Patients with muscle-specific tyrosine kinase (MuSK) antibody (MuSK-Ab)-positive myasthenia gravis (MG) show distinct responses to acetylcholinesterase inhibitors (AChEIs). Although clinical responses to AChEIs in MuSK-Ab MG are...
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The Clinical Features of Ocular Myasthenia Gravis in Thyroid-Associated Ophthalmopathy

Sohn EJ, Hur MC, Ahn HB

PURPOSE: There are some challenges to accurate diagnosis of ocular myasthenia gravis (MG) in thyroid-associated ophthalmopathy (TAO) patients because the clinical features of these diseases are similar. The aim of...
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Focal form of acquired myasthenia gravis with megaesophagus in a Yorkshire terrier dog

Hahn TY, Kang MH, Eom KD, Park HM

  • KMID: 1700793
  • Korean J Vet Res.
  • 2014 Mar;54(1):59-62.
A 12-year-old, castrated male Yorkshire terrier dog presented with frequent regurgitations that had begun 45 days earlier and become more progressive. Radiographs revealed an air-trap region behind the cranial esophageal...
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Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients

Woo T, Kim KS, Shim YH, Kim MK, Yoon SM, Lim YJ, Yang HS, Phiri P, Chon JY

BACKGROUND: Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing...
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Sugammadex: clinical development and practical use

Fuchs-Buder T, Meistelman C, Raft J

Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages...
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Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine

Yahng SA, Yoon JH, Shin SH, Lee SE, Eom KS, Kim YJ

Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie's syndrome, is a rare clinical syndrome of massive large bowel dilatation without mechanical obstruction, which may cause significant morbidity and mortality. Treatment...
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The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient

Nikolic A, Rakocevic Stojanovic V, Romac S, Savic D, Basta I, Lavrnic D

BACKGROUND: Myasthenia gravis (MG) and myotonic dystrophy type 2 (DM2) are rare disorders individually, and their coexistence in the same patient is very rare. We present a patient in which...
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A Case of Acute Colonic Pseudo-Obstruction Combined with Rhabdomyolysis induced by Severe Hypokalemia

Lee WH, Lee DY, Seo JH, Kang GW, Kwon JG, Lee IH

  • KMID: 2082470
  • Korean J Med.
  • 2013 Apr;84(4):591-596.
Acute colonic pseudo-obstruction (ACPO) or Ogilvie's syndrome is a rare disorder of intestinal motility characterized by massive colonic dilatation without mechanical obstruction. We report a case of ACPO combined with...
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