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Korean J Lab Med.  2006 Aug;26(4):246-248. 10.3343/kjlm.2006.26.4.246.

Chronic Myelogenous Leukemia with a Variant Philadelphia Translocation: t(11;22)(q25;q11.2)

Affiliations
  • 1Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
  • 2Department of Laboratory Medicine, Sungkyunkwan Univerity School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 3Department of Laboratory Medicine, Inha University College of Medicine, Incheon, Korea. moonys@inha.ac.kr

Abstract

We report a case of chronic myelogenous leukemia displaying a variant Philadelphia translocation t(11;22)(q25;q11.2). Breakpoint 11q25 has not previously been reported. Reverse transcriptase polymerase chain reaction and fluorescence in-situ hybridization demonstrated the BCR/ABL rearrangement.

Keyword

Variant Philadelphia; t(11;22)(q25;q11.2); Chronic myelogenous leukemia

MeSH Terms

Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Reverse Transcriptase Polymerase Chain Reaction
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