Korean J Lab Med.  2003 Jun;23(3):139-142.

A Case of Chronic Myelogenous Leukemia with ider(22)(q10)t(9;22)(q34;q11.2) as Clonal Evolution

Affiliations
  • 1Department of Laboratory Medicine, College of Medicine, Yeungnam University. chscp@hanmail.net
  • 2Department of Internal Medicine, College of Medicine, Yeungnam University.
  • 3Department of Internal Medicine, College of Medicine, Daegu Catholic University, Daegu, Korea.

Abstract

The ider(22)(q10)t(9;22)(q34;q11.2) is a rare secondary karyotypic aberration of Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) and was associated with disease progression and poor clinical outcomes in most of the previously reported cases. We experienced a case of Ph+ CML with the occurrence of ider(22)(q10)t(9;22)(q34;q11.2) as clonal evolution preceding an hematologic feature of accelerated phase for 3 years. So this chromosomal abnormality was not always correlated with poor prognosis. Relevant literature was reviewed.

Keyword

Ider(22)(q10)t(9;22)(q34;q11.2); Clonal evolution; Ph+ CML

MeSH Terms

Chromosome Aberrations
Clonal Evolution*
Disease Progression
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Philadelphia Chromosome
Prognosis
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