Korean J Anesthesiol.  2012 Dec;63(6):521-526. 10.4097/kjae.2012.63.6.521.

The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers

• Safari F
• Dabbagh A
• Sharifnia

• KMID: 2236253
• DOI: http://doi.org/10.4097/kjae.2012.63.6.521

Abstract

BACKGROUND
There are a number of adjuvants to be used for local anesthetics in spinal block. The aim of this study was to demonstrate the possible effect of intrathecal midazolam compared with bupivacaine as adjuvants in spinal anesthesia with bupivacaine in chronic opium abuses.
METHODS
In a double blind, randomized clinical trial, 90 opium abuser patients undergoing lower limb orthopedic surgery were selected and randomly assigned into 3 groups (30 cases each). The patients received 15 mg plain bupivacaine, or 15 mg bupivacaine plus 25 mcg fentanyl or 15 mg bupivacaine plus 1 mg midazolam, intrathecally.
RESULTS
The duration of anesthesia was much longer in the bupivacaine-midazolam group than the bupivacaine-fentanyl group; both were longer than the plain bupivacaine group (P < 0.05).
CONCLUSIONS
Subarachnoid injection of adjuvant midazolam or fentanyl with plain 0.5% bupivacaine in opium abusers in lower limb orthopedic surgery increases the duration of sensory block. Therefore midazolam is more effective than fentanyl in such cases.

Keyword

Adjuvant; Fentanyl; Intrathecal; Midazolam; Spinal anesthesia

MeSH Terms

Anesthesia
Anesthesia, Spinal
Anesthetics, Local
Bupivacaine
Fentanyl
Humans
Lower Extremity
Midazolam
Opium
Orthopedics
Anesthetics, Local
Bupivacaine
Fentanyl
Midazolam
Opium