Korean Circ J.  1991 Dec;21(6):1225-1230. 10.4070/kcj.1991.21.6.1225.

A Study of Antihypertensive Effect of Amlodipine

• Kwon HM
• Kim HS
• Jang YS
• Lim SU
• Sin ET
• Kim KC
• Kim HS

• KMID: 2229006
• DOI: http://doi.org/10.4070/kcj.1991.21.6.1225

Abstract

We evaluated the antihypertensive effect of amlodipine, a calcium channel bloker, in 35 cases of essential hypertention. After 12 weeks' administration(5~10mg q.d.), the following results were obtained : 1) The systoloic and diastolic blood pressure were decreased significantly(170.3+/-12.2mmHg vs 143.7+/-13.0mmHg p<0.01 and 104.7+/-5.9mmHg vs 87.8+/-6.5mmHg, p<0.01, respectively) but the heart rate was independant of amlodipine administration. 2) The systolic blood pressure was lowered by 20mmHg or more in 26(76.5%) of 34 patients and the diastolic pressure was lowered by 10mmHg or more in 26(76.5%) of 34 patients at 12 weeks after amlodipine administration. 3) The adverse effects of amlodipine were dizziness in 5, edema in 5, indigestion in 3, constipation in 2, headache, flushing, insomnia in 1 patient respectively and only one of them discontinued amlodipine administration due to severs facial flushing and skin eruption.

Keyword

Amlodipine; Antihypertensive drug

MeSH Terms

Amlodipine*
Blood Pressure
Calcium Channels
Constipation
Dizziness
Dyspepsia
Edema
Flushing
Headache
Heart Rate
Humans
Skin
Sleep Initiation and Maintenance Disorders
Amlodipine
Calcium Channels