- Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts
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You SC, Jung S, Swerdel JN, Ryan PB, Schuemie M, Suchard MA, Lee S, Cho J, Hripcsak G, Park RW, Park S
- KMID: 2465664
- Korean Circ J.
- 2020 Jan;50(1):52-68.
- doi: 10.4070/kcj.2019.0173
BACKGROUND AND OBJECTIVES: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited. We aimed to compare the effectiveness... -
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- Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⺠signaling of differentiated C2C12 myotubes
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Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM
- KMID: 2461047
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):539-547.
- doi: 10.4196/kjpp.2019.23.6.539
Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane... -
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- Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists
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Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH
- KMID: 2461036
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):427-448.
- doi: 10.4196/kjpp.2019.23.6.427
Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and... -
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- The relaxant effect of nicardipine on the isolated uterine smooth muscle of the pregnant rat
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Kim DJ, Hwang MH, An TH, Jung KT
- KMID: 2465341
- Anesth Pain Med.
- 2019 Oct;14(4):429-433.
- doi: 10.17085/apm.2019.14.4.429
BACKGROUND: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the... -
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- Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
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Noh J, Chung JM
- KMID: 2463713
- Exp Neurobiol.
- 2019 Oct;28(5):578-592.
- doi: 10.5607/en.2019.28.5.578
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state... -
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- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties
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Park S, Sohn JW, Cho J, Huh Y
- KMID: 2463712
- Exp Neurobiol.
- 2019 Oct;28(5):568-577.
- doi: 10.5607/en.2019.28.5.568
The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency... -
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- Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells
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Vu TT, Dieterich , Vu TT, Deussen A
- KMID: 2455811
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):345-356.
- doi: 10.4196/kjpp.2019.23.5.345
Docosahexaenoic acid (DHA), an omega-3-fatty acid, modulates multiple cellular functions. In this study, we addressed the effects of DHA on human umbilical vein endothelial cell calcium transient and endothelial nitric... -
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- Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors
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Oh J, Lee C, Kaang BK
- KMID: 2450491
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):237-249.
- doi: 10.4196/kjpp.2019.23.4.237
Confirming the direct link between neural circuit activity and animal behavior has been a principal aim of neuroscience. The genetically encoded calcium indicator (GECI), which binds to calcium ions and... -
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- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat
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Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD
- KMID: 2432073
- Biomol Ther.
- 2019 Jan;27(1):101-106.
- doi: 10.4062/biomolther.2018.136
Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder... -
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- Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy for Treatment of Calcium Channel Blockers, Angiotensin II Receptor Blockers, and Metformin Overdose
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Jeong JH, Sun KH, Park YJ, Kim SP
- KMID: 2437756
- J Korean Soc Clin Toxicol.
- 2018 Dec;16(2):165-171.
- doi: 10.22537/jksct.2018.16.2.165
An overdose of antihypertensive agents, such calcium channel blockers (CCBs) and angiotensin II receptor blocker (ARBs), and the antihyperglycemic agent, metformin, leads to hypotension and lactic acidosis, respectively. A 40-year-old hypertensive... -
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- Association between a Genetic Variant of CACNA1C and the Risk of Schizophrenia and Bipolar I Disorder Across Diagnostic Boundaries
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Lee B, Baek JH, Cho EY, Yang SY, Choi YJ, Lee YS, Ha K, Hong KS
- KMID: 2423026
- Korean J Schizophr Res.
- 2018 Oct;21(2):43-50.
- doi: 10.16946/kjsr.2018.21.2.43
OBJECTIVES: Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and... -
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- T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells
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Kim JW, Oh HA, Lee SH, Kim KC, Eun PH, Ko MJ, Gonzales E, Seung H, Kim S, Bahn GH, Shin CY
- KMID: 2421721
- Biomol Ther.
- 2018 Sep;26(5):439-445.
- doi: 10.4062/biomolther.2017.223
T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder... -
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- A Portulaca oleracea L. extract promotes insulin secretion via a Kâº(ATP) channel dependent pathway in INS-1 pancreatic β-cells
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Park JE, Han JS
- KMID: 2442291
- Nutr Res Pract.
- 2018 Jun;12(3):183-190.
- doi: 10.4162/nrp.2018.12.3.183
BACKGROUND/OBJECTIVE: This study was designed to investigate how a Portulaca oleracea L. extract (POE) stimulates insulin secretion in INS-1 pancreatic β-cells. MATERIALS/METHOD: INS-1 pancreatic β-cells were incubated in the presence of... -
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- The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity
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Ha DM, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Lim D, Kang C
- KMID: 2436259
- J Korean Soc Clin Toxicol.
- 2018 Jun;16(1):9-14.
- doi: 10.22537/jksct.2018.16.1.9
PURPOSE: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated... -
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- Skin Barrier and Calcium
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Lee SE, Lee SH
- KMID: 2419166
- Ann Dermatol.
- 2018 Jun;30(3):265-275.
- doi: 10.5021/ad.2018.30.3.265
Epidermal barrier formation and the maintenance of barrier homeostasis are essential to protect us from the external environments and organisms. Moreover, impaired keratinocytes differentiation and dysfunctional skin barrier can be... -
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- Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus
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Kim JH, Sohn UD, Kim HG, Kim HR
- KMID: 2410092
- Korean J Physiol Pharmacol.
- 2018 May;22(3):277-289.
- doi: 10.4196/kjpp.2018.22.3.277
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central... -
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- Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison
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Mehta RT, Pareek A, Purkait I
- KMID: 2434258
- Clin Hypertens.
- 2018 ;24(1):4.
- doi: 10.1186/s40885-018-0089-1
We have read the study design “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic... -
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- In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity
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Kim BH, Sun KH, Kim SP, Park Y
- KMID: 2402615
- J Korean Soc Clin Toxicol.
- 2017 Dec;15(2):107-115.
- doi: 10.22537/jksct.2017.15.2.107
PURPOSE: Glehnia littoralis has been used to treat ischemic stroke, phlegm, cough, systemic paralysis, antipyretics and neuralgia. The pharmacological mechanisms of Glehnia littoralis include calcium channel block, coumarin derivatives, anticoagulation,... -
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- A Prospective Survey of Atrial Fibrillation Management for Real-world Guideline Adherence: COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) Registry
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Kim H, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Kang KW, Shim J, Uhm JS, Kim J, Park HW, Choi EK, Kim JB, Kim C, Lee YS, Joung B
- KMID: 2396481
- Korean Circ J.
- 2017 Nov;47(6):877-887.
- doi: 10.4070/kcj.2017.0146
BACKGROUND AND OBJECTIVES: The aging population is rapidly increasing, and atrial fibrillation (AF) is becoming a significant public health burden in Asia, including Korea. This study evaluated current treatment patterns... -
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- The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery
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Hao N, Zhaojun W, Kuang S, Zhang G, Deng C, Ma J, Cui J
- KMID: 2395253
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):591-598.
- doi: 10.4196/kjpp.2017.21.6.591
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol... -
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