J Korean Ophthalmol Soc.  2014 Oct;55(10):1481-1486. 10.3341/jkos.2014.55.10.1481.

The Change of Microaneurysm in Diabetic Retinopathy Patients Who Undergo Intravitreal Avastin (Bevacizumab) Injection

• Choi CW
• Lee SJ
• Kang HR
• Yang YS

• KMID: 2216866
• DOI: http://doi.org/10.3341/jkos.2014.55.10.1481

Abstract

PURPOSE
To evaluate microvascular change (microaneurysm) in diabetic retinopathy patients who undergo intravitreal bevacizumab injection using fluorescein angiography (FAG).
METHODS
Thirty one eyes of 31 diabetic retinopathy patients undergoing intravitreal bevacizumab injection (1.25 mg/0.05 mL) in only 1 eye were included in this study. The control group (31 eyes) consisted of the fellow eyes. We excluded cased with intravitreal bevacizumab injection in both eyes and medial opacity obscuring three fundus image due to vitreous hemorrhage. The microaneurysmal change was analyzed at the same site the circle with optic disc radius and macula using FAG 2 to 4 months after injection.
RESULTS
The average number of microaneurysms was 42.58 +/- 33.93 and significantly decreased to 28.74 +/- 28.06 after intravitreal bevacizumab injection (p < 0.05). The decrease of 35.70 +/- 24.79% in the treatment group was statistically higher than 13.95 +/- 38.21% in the control group with the fellow eyes (p < 0.05).
CONCLUSIONS
In the present study, intravitreal bevacizumab injection reduced neovascularization, cystoid macular edema. Therefore this data can be used for future research on microvascular changes in the retina.

Keyword

Bebacizumab (Avastin); Diabetic retinopathy; Vascular endothelial growth factor (VEGF)

MeSH Terms

Diabetic Retinopathy*
Fluorescein Angiography
Humans
Macular Edema
Radius
Retina
Vitreous Hemorrhage
Bevacizumab

Figure

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  Figure 1. Microaneurysm of preinjectional state (A, B) and at 8 week postinjectional state (C, D) after intravitreal bevacizumab injection. The circle with a radius of optic disc and macular (red line) (A, C = patients #24 in Fig. 2, 3) (B, D = patients #30 in Fig. 2, 3).

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  Figure 2. The change of microaneurysm between pre intravitreous bevacizumab injection (IVB) and post IVB by fluorescein angiography (FAG).

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  Figure 3. Comparison between intravitreous bevacizumab injection (IVB) group and control group in microaneurysm changes.

Reference

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