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Clinical Outcomes of ATOS-mediated SmartSight Lenticule Extraction

Lee CM, Yoon HS, Kang HR, Kim M, Joh SC, Yeom DJ

Purpose: To evaluate the clinical outcomes of a new refractive corneal lenticule extraction method (SmartSight) using a Schwind ATOS femtosecond laser (Schwind Eye-Tech-Solutions, Kleinostheim, Germany). Methods: The medical records of 338...
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Desensitization for the prevention of drug hypersensitivity

Yun JE, Jeong J, Kang HR

Drug desensitization is a treatment strategy for patients with hypersensitivity to essential drugs without alternatives. The gradual increase in the drug dosage from low doses to therapeutic levels induces a...
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A Case of Generalized Maculopapular Rash Induced by Letrozole and Anastrozole

Kim S, Kim HJ, Yoon J, Seo JH, Lee JY, Kang HR

Aromatase inhibitors are widely used as a treatment for postmenopausal women with hormone receptor-positive breast cancer. They are classified as type 1 steroidal or type 2 nonsteroidal agents. Letrozole and...
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An Overview on the Adverse Reactions of H1-Antihistamine

Ahn KM, Kim HJ, Kang HR

Histamine is one of the most essential biochemical molecules involved in various responses, including inflammation, neurotransmission, and cell proliferation, in diverse organs. Clinical manifestations of allergic diseases are often triggered...
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Hypersensitivity Reactions to Anticancer Monoclonal Antibodies

Choi B, Jang HY, Kang HR, Oh JM

Therapeutic monoclonal antibodies (TmAbs) are new treatment options for cancer. While their use is more common, hypersensitivity reactions (HSRs) to these drugs have been increased, preventing the use of first-line therapies....
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Management of hypersensitivity reactions to contrast media

Seo JH, Jeong J, Yun JE, Lee SY, Kang HR

As imaging technologies have become essential for diagnosing various diseases, the use of contrast agents is rapidly expanding. As a result, hypersensitivity reactions (HSRs) to contrast agents have also increased....
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Mesenchymal Stem Cells Attenuate Asthmatic Inflammation and Airway Remodeling by Modulating Macrophages/Monocytes in the IL-13-Overexpressing Mouse Model

Mo Y, Kim Y, Bang JY, Jung J, Lee CG, Elias JA, Kang HR

Mesenchymal stem cells (MSCs) are attractive alternatives to conventional anti-asthmatic drugs for severe asthma. Mechanisms underlying the anti-asthmatic effects of MSCs have not yet been elucidated. This study evaluated the...
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A Case Report of Guaifenesin-Induced Anaphylaxis

Yoon J, Kim HJ, Seo JH, Kang HR

Guaifenesin (glyceryl guaiacolate) is widely used as an expectorant by reducing the viscosity and increasing the volume of bronchial secretions. It is usually used as a combination complex with acetaminophen,...
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A Case of Atypical Fixed Drug Eruption Induced by Erdosteine

Choi JW, Kim HJ, Yoon J, Seo JH, Lee JY, Kang HR

Erdosteine is a mucolytic agent used in acute and chronic respiratory disease and it is known to be well tolerated. Adverse drug reactions related with erdosteine are mostly mild gastrointestinal...
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A successful shortening of desensitization protocol in a patient with cetuximab anaphylaxis

Seo JH, Jung J, Yoon JE, Kim HH, Kim HJ, Lee SY, Kang HR

Desensitization therapy can help overcome severe hypersensitivity reactions and allow continuing administration of the culprit agents. However, this is time- and labor-intensive due to a prolonged infusion time and the...
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Cigarette smoke extract contributes to the inception and aggravation of asthmatic inflammation by stimulating innate immunity

Kim Y, Kim J, Mo Y, Park DE, Lee HS, Jung JW, Kang HR

Purpose: Smoking is a risk factor for the development of asthma and worsens the long-term prognosis of asthma. This study investigated the effect of cigarette smoke extract (CSE) on innate...
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Management of hereditary angioedema in pediatric, pregnant, and breast-feeding patients: An expert opinion

Yoon SY, Jung JW, Park SY, Kim GW, Son K, Kang SY, Park HJ, Kang MK, Kim JH, Park KH, Lee DH, Kim SH, Kwon HS, Kang HR, Suh DI

Hereditary angioedema (HAE) is a rare inherited condition marked by recurrent skin and submucosal edema. HAE is caused by a C1 inhibitor deficiency or decreased C1 inhibitor function. The initial...
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Diagnosis and treatment of hereditary angioedema: An expert opinion

Jung JW, Park SY, Yoon SY, Kim GW, Sohn KH, Kang SY, Park HJ, Kang MK, Kim JH, Park KH, Suh DI, Lee DH, Kim SH, Kwon HS, Kang HR

Hereditary angioedema (HAE) is a rare disease, but it severely interrupts daily life activities and can sometimes be life-threatening. Therefore, early diagnosis and prompt treatment of HAE attacks are critical....
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Analysis of Fluoroquinolone Adverse Drug Reaction Reported in a Single Center

Kim HJ, Hwang S, Kim HH, Jang JY, Suh JH, Kang DY, Lee JY, Kang HR

Objective: With the increased use of fluoroquinolone in the clinical setting, adverse drug reactions (ADR) to fluoroquinolones are also on the rise. The purpose of this study was to analyze...
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Desensitization for the prevention of drug hypersensitivity reactions

Kang SY, Seo J, Kang HR

Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose....
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Expert opinion: The clinical usefulness of skin tests prior to the administration of beta-lactam antibiotics

Kim SR, Kim S, Kim SH, Park JS, Park HJ, Suh DI, Sim DW, Yang MS, Lee JH, Lee HY, Jung JW, Choi M, Kang HR, Drug Allergy Working Group of Korean Academy of Asthma Allergy and Clinical Immunology

An allergy skin test is used to diagnose certain allergies by identifying sensitized allergens. In other words, it is a test for patients who are already sensitized to certain allergens....
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Pathophysiology, diagnosis, and management of chronic pruritus

Ahn YH, Kang HR

“Itch” is an unpleasant sensation that elicits a desire to scratch. It is a common complaint among many patients and is associated with a markedly reduced quality of life. The...
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Adverse Drug Reactions to First-line Anti-tubercular Drugs Based on Individual Case Safety Report in a Single Tertiary Hospital

Kim HH, Moon M, Choi N, Kang DY, Chae KO, Lee J, Lim JJ, Cho SH, Kang HR

Background/Aims: Tuberculosis has incidence and mortality rates that are among the highest for all communicable diseases. Adverse drug reactions (ADRs) to anti-tubercular drugs are common, and have a major impact...
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Drug Labeling Status of Culprit Drugs Inducing Severe Cutaneous Adverse Reactions

Yeom HJ, Kim HHw, Kim HJ, Park S, Jang JY, Park GY, Kang DY, Kang HR

Objective: The labeling status of culprit drugs of Severe Cutaneous Adverse Reactions (SCAR) was evaluated by comparing the labeling status of the US Food and Drug Administration (FDA) to the...
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Adverse Reactions after the Second Dose of ChAdOx1 COVID-19 Vaccine in H ealthcare Workers

Kim HJ, Kim HH, Park S, Yeom HJ, Jang JY, Park Gy, Kang HR, Kang DY

Objective: The Seoul National University Hospital Drug Safety Monitoring Center performed a prospective survey regarding adverse reactions after the second dose of the adenovirus-vectored vaccine (ChAdOx1 nCoV-19) in healthcare workers....
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