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Safety and efficacy of nilotinib in adult patients with chronic myeloid leukemia: a post-marketing surveillance study in Korea

Ahn SY, Son SK, Lee GH, Kim I, Cheong JW, Lee WS, Kim BS, Jo DY, Jung CW, Seong CM, Lee JH, Yuh YJ, Kim MK, Ryoo HM, Park MR, Cho SH, Kim HG, Zang DY, Park J, Kim H, Lee S, Kim SH, Chang MH, Lee HS, Choi CW, Kwon J, Lim SN, Oh SJ, Joo I, Kim DW

Background Nilotinib is a tyrosine kinase inhibitor approved by the Ministry of Food and Drug Safety for frontline and 2nd line treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This...
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Olmesartan-associated Enteropathy with Acute Kidney Injury

Kang MJ, Min KH, Kim HW, Park SB, Kang DH, Choi CW, Kim SJ, Nam HS, Ryu DG

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Diazoxide-Associated Pulmonary Hyperten sion in an Infant with Beck with-Wiedemann Syndrome: A Case Report

Ryu JH, Kang D, Lee J, Ko JM, Jung YH, Kim JH, Choi CW

Diazoxide, an ATP-sensitive potassium channel opener, has been used as 1st line treatment for hyperinsulinemic hypoglycemia. As congenital hyperinsulinism is the most common cause of hyperinsulinemic hypoglycemia, diazoxide is more...
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Olmesartan-associated Enteropathy with Acute Kidney Injury

Kang MJ, Min KH, Kim HW, Park SB, Kang DH, Choi CW, Kim SJ, Nam HS, Ryu DG

Olmesartan, a recently introduced angiotensin II receptor blocker for hypertension, has been reported to cause drug-induced small bowel enteropathy. The diagnosis of olmesartan-associated enteropathy (OAE) needs clinical suspicion and the...
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Diagnosis and Treatment of Eosinophilic Esophagitis

Kim SJ, Choi CW, Hwang CS

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. The diagnostic criteria for EoE have changed with our growing knowledge over...
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The Prediction of HER2-Targeted Treatment Response Using 64CuTetra- Azacyclododecanetetra-Acetic Acid (DOTA)-Trastuzumab PET/CT in Metastatic Breast Cancer: A Case Report

Lee I, Lim I, Byun BH, Kim BI, Choi CW, Lee KC, Kang CM, Seong MK, Kim HA, Noh WC, Lim SM

A 45-year-old woman diagnosed with breast cancer reported disease progression in the form of metastatic lung and recurrent breast lesions following chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted...
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Comparison of Clinical Outcomes in Patients Undergoing a Salvage Procedure for Thrombosed Hemodialysis Arteriovenous Grafts

Park YK, Lim JW, Choi CW, Her K, Shin HK, Shinn SH

Background: The major limitation of arteriovenous graft access is the high incidence of thrombotic occlusion. This study investigated the outcomes of our salvage strategy for thrombosed hemodialysis arteriovenous grafts (including...
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Azidothymidine Downregulates Insulin-Like Growth Factor-1 Induced Lipogenesis by Suppressing Mitochondrial Biogenesis and Mitophagy in Immortalized Human Sebocytes

Yoo JG, Li XM, Lee JK, Park S, Hong D, Jung KE, Lee Y, Seo YJ, Kim CD, Shin JM, Choi CW

Background: Increased sebum secretion is considered the main causative factor in the pathogenesis of acne. There is an unmet pharmacological need for a novel drug that can control sebum production...
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Tumor grade 2 as the independent predictor for lymph node metastasis in 10–20 mm sized rectal neuroendocrine tumor

Park BS, Cho SH, Son GM, Kim HS, Kim SJ, Park SB, Choi CW, Kim HW, Shin DH

Purpose: Rectal neuroendocrine tumors (NETs)
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Endoscopic Features of Submucosal Invasion in Undifferentiated-type Early Gastric Cancer Less than 20 mm in Size without Ulceration

Kim SJ, Park BS, Choi CW, Kim HW, Kang DH, Park SB

Background/Aims: The prediction of invasion depth is important to decide the treatment modality for undifferentiated-type early gastric cancer (EGC) less than 20 mm in size without ulceration. We aimed to...
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Polydeoxyribonucleotide Attenuates Airway Inflammation Through A2AR Signaling Pathway in PM10-Exposed Mice

Hwang L, Jin JJ, Ko IG, Kim S, Cho YA, Sung JS, Choi CW, Chang BS

Purpose: Inhalation of air containing high amounts of particular matter (PM) causes various respiratory disorders including asthma, chronic obstructive pulmonary disease, and lung cancer. The changes of expression of inflammatory...
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Predictor of Subungual Melanoma against Benign Longitudinal Melanonychia: A Retrospective Cohort Study from Korea

Yim SH, Kwon IS, Hong D, Jung KE, Lee Y, Seo YJ, Choi CW

Background: Longitudinal melanonychia (LM) is a common clinical finding. Most cases of LM are benign, and a waitand-see approach is preferred in the management of this condition. Nevertheless, it is...
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Clinical features of internal hernia after gastrectomy for gastric cancer

Ahn Hm, Lee SH, Jeon TY, Kim DH, Choi CI, Kim SJ, Choi CW, Kim TU, Kim KH, Hwang SH

Purpose: Internal hernia after gastrectomy is a rare but potentially life-threatening condition without surgical intervention. Clinical risk factors of internal hernia should, hence, be reviewed after gastrectomy. From 2008 to 2018,...
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Endoscopic removal of swallowed acupuncture needle infiltrated into the kidney from the duodenum

Ryu DG, Choi CW, Kim SJ, Kang DH, Kim HW

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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells

Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW

Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of...
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Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019: Expert Recommendations from The Korean Society for Thoracic and Cardiovascular Surgery

Jeong IS, Kim WH, Baek JH, Choi CH, Choi CW, Chung ES, Jang JS, Jang WS, Jung H, Jung JS, Kang PJ, Kim DJ, Kim DW, Kim HS, Kim JB, Kim WS, Kim YS, Kwak JG, Lee H, Lee SI, Lim JW, Oh SJ, Oh TH, Park CS, Ryu KM, Shim MS, Son J, Son KH, Song S, on behalf of The Korean Society for Thoracic and Cardiovascular Surgery COVID-19 ECMO Task Force Team

Since the first reported case of coronavirus disease 2019 (COVID-19) in December 2019, the numbers of confirmed cases and deaths have continued to increase exponentially despite multi-factorial efforts. Although various...
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The 2020 revision of the guidelines for the management of myeloproliferative neoplasms

Kim SY, Bae SH, Bang SM, Eom KS, Hong J, Jang S, Jung CW, Kim HJ, Kim HY, Kim MK, Kim SJ, Mun YC, Nam SH, Park J, Won JH, Choi CW

In 2016, the World Health Organization revised the diagnostic criteria for myeloproliferative neoplasms (MPNs) based on the discovery of disease-driving genetic aberrations and extensive analysis of the clinical characteristics of...
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The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation

Lee SH, Choi CW

Background: Animal studies have shown that a leukocyte influx precedes the development of bronchopulmonary dysplasia (BPD) in premature sheep. The CXC chemokine receptor 2 (CXCR2) pathway has been implicated in...
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Extracorporeal Membrane Oxygenation Treatment in Coronavirus Disease 2019: Two Cases

Choi CW

Among the clinical symptoms of coronavirus disease 2019 (COVID-19), acute respiratory dysfunction syndrome (ARDS) is the most rapid and fatal form of clinical symptoms, and since conventional treatment cannot achieve...
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Non-surgical treatment of vitiligo

Choi CW

Vitiligo is an acquired depigmenting skin disorder that affects 0.5% to 2% of the population. Skin lesions from vitiligo, white macules and patches on the skin, can pose a substantial...
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