J Korean Ophthalmol Soc.  2011 Mar;52(3):293-298. 10.3341/jkos.2011.52.3.293.

Intravitreal Bevacizumab for Treatment of Macular Edema Secondary to Hemicentral Retinal Venous Occlusion and Concentrations of Cytokine in Aqueous Humor

• Ryu SJ
• Lim JW

• KMID: 2214293
• DOI: http://doi.org/10.3341/jkos.2011.52.3.293

Abstract

PURPOSE
To evaluate the effects of intravitreal bevacizumab and to investigate the concentrations of cytokine in the aqueous humors of patients with macular edema secondary to hemicentral retinal venous occlusion.
METHODS
Fifteen eyes of 15 patients with macular edema secondary to hemicentral retinal venous occlusion received intravitreal bevacizumab injections and completed 12 months of follow-up. Cytokine levels were measured in the aqueous humors of these patients using a multiplex bead assay and the levels were compared with those of the controls.
RESULTS
During 12 months of follow-up, a mean of 4.5 intravitreal bevacizumab injections were performed. The visual acuity and the central macular thickness improved significantly (p = 0.028, p = 0.000) after treatment. The levels of interleukin-6, vascular endothelial growth factor, and monocyte chemoattractant protein-1 were increased in the aqueous humor compared with the levels in the control group (p = 0.010, p = 0.045, p < 0.001).
CONCLUSIONS
Elevated cytokine levels were identified in the aqueous humor after hemicentral retinal venous occlusion. Intravitreal bevacizumab injections were effective for improvements in visual acuity and macular edema due to hemicentral retinal venous occlusion.

Keyword

Cytokine; Hemicentral retinal vein occlusion; Intravitreal bevacizumab; Macular edema

MeSH Terms

Antibodies, Monoclonal, Humanized
Aqueous Humor
Chemokine CCL2
Eye
Follow-Up Studies
Humans
Interleukin-6
Macular Edema
Retinaldehyde
Vascular Endothelial Growth Factor A
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Chemokine CCL2
Interleukin-6
Retinaldehyde
Vascular Endothelial Growth Factor A

Figure

• 

  Figure 1. Right eye of a 74-year-old man treated with intravitreal bevacizumab (A) Fundus photograph presenting hemi-retinal venous occlusion. (B) Fluorescein angiography showing no neovasculization or extensive non-perfusion areas. Aqueous VEGF level was 65.98 pg/mL and MCP-1 was 1058.33 pg/mL. (C) Optical coherence tomography at baseline. His visual acuity was 20/100. (D) 2 months after initial intravitreal bevacizumab, optical coherence tomography showed persistant macular edema. The second intravitreal bevacizumab was performed. (E) At month 4, the third intravitreal bevacizumab was performed. (F) At month 6, his visual acuity improved to 20/40 and the macula was stable up to 12 months.

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  Figure 2. Correlation analysis of the vascular endothelial growth factor in aqueous humor and the central macular thickness in patient with hemicentral retinal vein occlusion (Pearson correlation, r = 0.413; p = 0.047).

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  Figure 3. Correlation analysis of the monocyte chemoattractant protein-1 and vascular endothelial growth factor in aqueous humor in patient with hemicentral retinal vein occlusion (Pearson correlation, r = 0.509; p = 0.031).

Reference

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