J Korean Ophthalmol Soc.  2012 Aug;53(8):1112-1117. 10.3341/jkos.2012.53.8.1112.

Effects of Intravitreal Bevacizumab Injection in 3 Types of Macular Edema Secondary to Branch Retinal Vein Occlusion

• Jang YS
• Lee DW

• KMID: 2215953
• DOI: http://doi.org/10.3341/jkos.2012.53.8.1112

Abstract

PURPOSE
To compare the effects of intravitreal bevacizumab injection (IVB) in 3 types of macular edema secondary to branch retinal vein occlusion (BRVO).
METHODS
Patients with macular edema secondary to BRVO with at least 1-year follow-up after IVB were included in the present retrospective study. The authors classified the macular edema into 3 types according to OCT findings: diffuse macular edema (type 1), cystoid macular edema (type 2), and serous retinal detachment (type 3). The clinical outcome indicators were best corrected visual acuity, central macular thickness (CMT), and total number of injections.
RESULTS
The total injection number was significantly higher in type 2 than type 3 (p = 0.02). Changes in CMT were significantly different between type 2 and type 3 (p = 0.03). CMT decreased significantly after IVB in all types of macular edema.
CONCLUSIONS
Morphologic classification of macular edema with OCT is useful for predicting efficacy of IVB in macular edema secondary to BRVO.

Keyword

Avastin; BRVO; Intravitreal bevacizumab injection; Macular edema; OCT

MeSH Terms

Antibodies, Monoclonal, Humanized
Follow-Up Studies
Humans
Macular Edema
Retinal Detachment
Retinal Vein
Retinal Vein Occlusion
Retinaldehyde
Retrospective Studies
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde

Figure

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  Figure 1 Classification of macular edema in BRVO patients. Type I: diffuse macular edema. Type II: cystoids macular edema. Type III: serous retinal detachment.

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  Figure 2 Changes in visual acuity after intravitreal Bevacizumab injection. Type I: diffuse macular edema. Type II: cystoids macular edema. Type III: serous retinal detachment.

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  Figure 3 Changes in CMT after intravitreal bevacizumab injection. Type I: diffuse macular edema. Type II: cystoids macular edema. Type III: serous retinal detachment.

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