J Korean Surg Soc.  2010 Jun;78(6):385-389. 10.4174/jkss.2010.78.6.385.

Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day

• Kwak HD
• Choi DJ
• Woo SU
• Kim J
• Um JW
• Kim SH

• KMID: 2211969
• DOI: http://doi.org/10.4174/jkss.2010.78.6.385

Abstract

PURPOSE
We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection.
METHODS
The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection.
RESULTS
The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456).
CONCLUSION
Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.

Keyword

Antimicrobial prophylaxis; Monotherapy; Laparoscopic colorectal surgery; Surgical site infection; Hospital acquired infection

MeSH Terms

Academic Medical Centers
Body Mass Index
Colorectal Surgery
Diabetes Mellitus
Humans
Korea
Operative Time
Prospective Studies
Smoke
Smoking
Smoke

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