Infect Chemother.
2004 Feb;36(1):24-31.
Usage Analysis of Surgical Prophylaxis of Cephalosporins and Aminoglycosides in a University Hospital
- Affiliations
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- 1Department of Laboratory Medicine, Dankook University College of Medicine, Cheonan, Korea. insoo@dankook.ac.kr
- 2Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Anyang-Hospital, Anyang, Korea.
- 4Department of Internal Medicine, Ilsan Gospel Hospital, Ilsan, Korea.
- 5Division of QI, Dankook University Hospital, Cheonan, Korea.
Abstract
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BACKGROUND: According to previous investigation on antibiotic use at Dankook University Hospital, cephalosporin and aminoglycoside were the most commonly used antibiotics accounting for 52.8% and 30.4% of total antibiotics used, respectively. In almost all cases, antibiotics were prescribed for prophylaxis rather than for treatment the ratio for prophylaxis vs. treatment intent was 3.9:1 and 3.6: 1 for cephalosporin and aminoglycoside, respectively. Thus, we performed a study to investigate the current usage of cephalosporin and aminoglycoside before and after the surgical procedures.
METHODS
We retrospectively analyzed the appropriateness of prophylactic use of antibiotics on 14 major operative procedures (26.4% of total operations) for patients discharged during July, 1997.
RESULTS
Among 8 kinds of operative procedure performed on 105 cases, in which prophylactic antibiotic use was recommended, appropriate antibiotic use was observed in only 2 cases of non- perforating appendectomy. For 7 operative procedures, in which use of 1st generation cephalosporin is recommended, 1st cephalosporins were used only on 37.8% (44/92) of cases, whereas 2nd cephalosporins were used for most of other cases. An average of 2.5 DDD of 2nd cephalosporin, which was a pertinent dose, was used on non-perforating appendectomy. However, on all the other 7 operative procedures, the dose exceeded the recommended dose. Inappropriate antibiotic use was observed for 6 operative procedures, for which prophylactic antibiotic use was not recommended. The combination of cephalosporin and aminoglycoside was used in all but 3 types of operative procedures.
CONCLUSION
During most of the pre- and post-operative period, antibiotics were combined, overused, misused, and inappropriately used.
