J Korean Pediatr Soc.  1996 Nov;39(11):1611-1619.

Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia

  • 1Department of Pediatrics, Samsung Seoul Hospital, Seoul, Korea.
  • 2Department of Pediatric Surgery, Samsung Seoul Hospital, Seoul, Korea.


Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for treatment. Addition of ntiric oxide of 1-80 parts per million to the inspired gas allowed resolution of pulmonary hypertension. No side effect of nitric oxide therapy was observed, and ventilatory support could be substantially reduced as a result of treatment and could be stopped later. On the basis of the striking and lifesaving effects of nitric oxide therapy shown in these cases, we believe that nitric oxide inhalation can be used as a major treatment modality in the management of persistent pulmonary hypertension of the newborn.


NItric oxide; Congenital diaphragmatic hernia; Persistent pulmonary hypertension of newborn

MeSH Terms

Endothelium-Dependent Relaxing Factors
Hernia, Diaphragmatic*
Hypertension, Pulmonary*
Infant, Newborn
Nitric Oxide*
Persistent Fetal Circulation Syndrome
Strikes, Employee
Endothelium-Dependent Relaxing Factors
Nitric Oxide
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