Korean J Anesthesiol.  1999 Dec;37(6):1084-1088. 10.4097/kjae.1999.37.6.1084.

Inhaled Nitric Oxide as a Therapy for Pulmonary Hypertension after Operations for Congenital Heart Diseases

• Kim JH
• Lee KC
• Chang YJ
• Lim YT
• Park JC
• Cho YL

• KMID: 2031460
• DOI: http://doi.org/10.4097/kjae.1999.37.6.1084

Abstract

BACKGROUND: Congenital heart disease may be complicated by pulmonary hypertension. We assessed whether inhaled nitric oxide would produce selective pulmonary vasodilation in pediatric patients with congenital heart disease and pulmonary hypertension.
METHODS
Inhaled low dose (10 20 ppm) nitric oxide was administrated in patients who were at risk of pulmonary hypertension after operations for congenital heart disease. To identify the nitric oxide effects, we evaluated hemodynamic and ABGA data before (T0) and after (T1) inhaled nitric oxide and just before (T2) decreasing concentration of inhaled nitric oxide.
RESULTS
Inhaled nitric oxide decreased pulmonary arterial pressure and increased PaO2/FiO2 without decreasing systemic arterial pressure.
CONCLUSIONS
Inhaled nitric oxide selectively decreased pulmonary arterial pressure in patients with congenital heart disease complicated by pulmonary artery hypertension.

Keyword

Blood vessels, vasodilation; Gases, nonanesthetic, nitric oxide

MeSH Terms

Arterial Pressure
Heart Defects, Congenital
Heart Diseases*
Heart*
Hemodynamics
Humans
Hypertension
Hypertension, Pulmonary*
Nitric Oxide*
Pulmonary Artery
Vasodilation
Nitric Oxide