J Korean Pediatr Soc.  1999 Nov;42(11):1516-1523.

Implication of vacA s1 Genotype of Helicobacter pylori in Children

• Kim YJ
• Park HY
• Lee MA
• Seo JW

Abstract

PURPOSE: Recently vacA s1 genotype of Helicobacter pylori was known to be associated with enhanced inflammation and peptic ulceration. To evaluate the association of the vacA s1 genotype with enhanced inflammation and peptic ulceration in children, we performed a polymerase chain reaction(PCR) for vacA s1 genotype.
METHODS
Twenty-seven CLO test-positive children were enrolled. They also revealed histological detection of bacteria and positive ureC gene by PCR in gastric biopsy specimens. The vacA s1, s2 and cagA genotypes were assayed by PCR in gastric biopsy specimens.
RESULTS
There were no association between vacA s1 genotype with peptic ulceration, severe inflammatory reaction, histological density of H. pylori, and formation of lymphoid follicle. None of our patients showed intestinal metaplasia. The vacA s1 genotype with or without cagA gene was not associated with peptic ulceration and enhanced inflammation.
CONCLUSION
This study suggested that vacA s1 genotype of H. pylori was not associated with peptic ulceration and enhanced inflammation in Korean children.

Keyword

Helicobactoer pylori; vacA s1; cagA; Children

MeSH Terms

Bacteria
Biopsy
Child*
Genotype*
Helicobacter pylori*
Helicobacter*
Humans
Inflammation
Metaplasia
Peptic Ulcer
Polymerase Chain Reaction