J Korean Pediatr Soc.  2002 Aug;45(8):1028-1032.

A Case of Subcutaneous Panniculitis-like T Cell Lymphoma in Childhood

• Choi YS
• Shin KM
• Won SC
• Lyu CJ
• Yang CH
• Kim BS
• Kim MK

Abstract

Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical lymphoid cells infiltrating between adipocytes. The optimal treatment for this disease is undefined and prognosis of this disease is poor, even when treated with multiagent chemotherapy regimens considered optimal for agressive lymphoma of other types. Poor prognosis factors include clinical features such as anemia, leukocytopenia, hepatosplenomegaly, lymphadenopathy and coagulopathy, which are suggestive of hemophagocytosis. Much of the mortality of this disease is due not to disseminated lymphoma with organ failure, but rather to complications of the cytopenias associated with the hemophagocytic syndrome. We report a case of subcutaneous panniculitis-like T cell lymphoma in a 12 year-old boy who presented with initial complaints of fever and multiple subcutaneous nodules, and briefly review the related literature.

Keyword

Subcutaneous panniculitis-like T cell lymphoma

MeSH Terms

Adipocytes
Anemia
Child
Chills
Drug Therapy
Extremities
Fatigue
Fever
Humans
Leukopenia
Lymphatic Diseases
Lymphocytes
Lymphohistiocytosis, Hemophagocytic
Lymphoma
Lymphoma, T-Cell*
Lymphoma, T-Cell, Cutaneous
Male
Mortality
Myalgia
Panniculitis
Prognosis
Weight Loss