J Korean Ophthalmol Soc.
2003 Mar;44(3):727-731.
Inhibitory Effects of Taxol and Mitomycin C on Proliferation of Cultured Rabbit Subconjunctival Fibroblasts
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- 1Department of Ophthalmology, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Korea. jimoon@cmc.cuk.ac.kr
Abstract
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Scar tissue formation by proliferation, migration and contraction of fibroblasts may result in the failure of trabeculectomy. The author investigated inhibitory effects of Mitomycin C (MMC) and Taxol on proliferation of cultured rabbit subconjunctival fibroblasts. METHODS: Tenon's fibroblasts of rabbits were cultured and exposed to various concentrations of each drug for 6 days. Cell viability was measured using MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay. RESULTS: Both MMC and Taxol inhibited proliferation of fibroblasts significantly in a dose-dependent manner, with ID50s of 0.27 mg/l and 0.08 mg/l, respectively. CONCLUSIONS: We have confirmed that Taxol is as potent inhibitor of fibroblast proliferation as Mitomycin C. This result may possibly support the use of Taxol in trabeculectomy to improve the success rate of trabeculectomy.
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