J Korean Ophthalmol Soc.  2002 Sep;43(9):1781-1788.

The Effect of Intravitreal Melatonin on Rabbit Retina

• Kim DG
• Sohn WS
• Kwak HW

Abstract

PURPOSE: To investigate the effect of intravitreal melatonin on retina in rabbit.
METHODS
In four pigmented rabbit, melatonin was intravitreally injected 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration in left eye, DMSO was injected in right eye as control. we examined gross fundus finding and electroretinogram and then light and electronic microscopic findings at 24 hours and 1 week with both eye.
RESULTS
intravitreally melatonin injected eye at 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration and control eye at 1 day and 1 week, significant difference was not shown in gross fundus finding, electroretinogram, light and electronic microscopic finding. Additionally edema, toxic effect change was not found in retina.
CONCLUSIONS
Intravitreally injected melatonin has not influenced on retina grossly, histologically, physiologically at 100 mu g/0.1 ml and 300 mu g/0.1 ml concentration. Further study is required about toxic effect of melatonin over 300 mu g/0.1 ml concentration and clinical usefulness of melatonin in retina.

Keyword

Antioxidant; Free radical scavenger; Intravitreal injection; Melatonin; Retinal toxicity

MeSH Terms

Dimethyl Sulfoxide
Edema
Intravitreal Injections
Melatonin*
Retina*
Dimethyl Sulfoxide
Melatonin