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Effect of melatonin on the onset of puberty in male juvenile rats

Venugopal

Melatonin or N-acetyl-5-methoxytryptamine, the fascinating molecule secreted by the pineal gland. Melatonin has a close interaction with hypothalamic-pituitary-gonadal axis. In non-seasonal breeders like rat its exact role in reproduction is...
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Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells

Jo SH, Lee SH, Kim KT, Choi SY

Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial...
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The Evaluation of Exogenous Melatonin Administration in Supraspinatus Overuse Tendinopathy in an Experimental Rat Model

Kocadal O, Pepe M, Akyurek N, Gunes Z, Surer H, Aksahin E, Ogut B, Aktekin CN

BACKGROUND: Increased oxidative stress and inflammation play a critical role in the etiopathogenesis of chronic tendinopathy. Melatonin is an endogenous molecule that exhibits antioxidant and anti-inflammatory activity. The aim of...
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Does Melatonin and Melatonin Agonists Improve the Metabolic Side Effects of Atypical Antipsychotics?: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Igwe SC, Brigo F

Atypical antipsychotics (AAPs) are increasingly used for the treatment of psychotic disorders but are known to be associated with metabolic abnormalities. This study is a systematic review and meta-analysis of...
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Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

Yun SP, Han YS, Lee JH, Kim SM, Lee SH

p-Cresol, found at high concentrations in the serum of chronic kidney failure patients, is known to cause cell senescence and other complications in different parts of the body. p-Cresol is...
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Field Study of Effects of Night Shifts on Cognitive Performance, Salivary Melatonin, and Sleep

Kazemi R, Motamedzade M, Golmohammadi R, Mokarami H, Hemmatjo R, Heidarimoghadam R

BACKGROUND: Night shift work is associated with many problems such as sleep deprivation, sleepiness, decreased cognitive performance, increased human errors, and fatigue. This study set out to measure cognitive performance,...
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Melatonin for Treatment of Delirium in Hospitalized Patients : Retrospective Trial

Yang JW, Kim JW, Kang WS, Lee SM, Kim YJ, Paik JW

OBJECTIVES: Delirium is one of the most common mental illnesses that can affect cognitive function. Melatonin has been shown to be effective in the treatment of insomnia, and recent studies...
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The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs

Wu Y, Si F, Luo L, Jing F, Jiang K, Zhou J, Yi Q

The effect of melatonin on juveniles with cardio fibrosis is poorly understood. We investigated whether HDACs participate in the anti-fibrotic processes regulated by melatonin during hypertrophic remodeling. Abdominal aortic constriction...
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The effect of a blue enriched white light on salivary antioxidant capacity and melatonin among night shift workers: a field study

Kazemi R, Hemmatjo R, Hamidreza

BACKGROUND: Because of their positive impact on individuals’ performance and alertness, blue enriched white light sources are gaining popularity in households and industries. However, these sources of blue light spectrum...
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Melatonin Rescues Human Dental Pulp Cells from Premature Senescence Induced by Hâ‚‚Oâ‚‚

Park S, Bak KJ, Ok CY, Park HJ, Jang HO, Bae MK, Bae SK

Although anti-aging activities of melatonin, a hormone secreted by the pineal gland, have been reported in senescence-accelerated mouse models and several types of cells, its impact and mechanism on the...
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Melatonin Protects Human Adipose-Derived Stem Cells from Oxidative Stress and Cell Death

Tan SS, Han X, Sivakumaran P, Lim SY, Morrison W

BACKGROUND: Adipose-derived stem cells (ASCs) have applications in regenerative medicine based on their therapeutic potential to repair and regenerate diseased and damaged tissue. They are commonly subject to oxidative stress...
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Modulation of axonal sprouting along rostro-caudal axis of dorsal hippocampus and no neuronal survival in parahippocampal cortices by long-term post-lesion melatonin administration in lithium-pilocarpine model of temporal lobe epilepsy

Kazemi M, Shokri S, Ganjkhani , Ali R, Iraj JA

Feature outcome of hippocampus and extra-hippocampal cortices was evaluated in melatonin treated lithium-pilocarpine epileptic rats during early and chronic phases of temporal lobe epilepsy (TLE). After status epilepticus (SE) induction,...
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Genoprotective Effect of Melatonin Against to the Genotoxicity of Glyphosate on Human Blood Lymphocytes

Kim JG, Choi WI, Lee JH, Choi IJ, Jin SC

PURPOSE: Glyphosate is a widely used non-selective herbicide. Previous studies have shown that glyphosate has genotoxicity, and that even low-doses of glyphosate can cause DNA damage. Melatonin is a hormone...
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Melatonin in Psychiatric Disorders

Lee JS, Kim SG, Kim JH, Jung WY, Park JH

The secretion of melatonin exhibits a circadian rhythm entrained with the sleep-wake cycle. An alteration of this secretory rhythm has been found in various psychiatric disorders. This review summarizes the...
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Melatonin Attenuates Noise Stress-induced Gastrointestinal Motility Disorder and Gastric Stress Ulcer: Role of Gastrointestinal Hormones and Oxidative Stress in Rats

Zhang L, Gong JT, Zhang HQ, Song QH, Xu GH, Cai L, Tang XD, Zhang HF, Liu FE, Jia ZS, Zhang HW

  • KMID: 2381251
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):189-199.
  • doi: 10.5056/jnm14119
BACKGROUND/AIMS: There are increasing evidences for gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on...
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Comparison of the Effects of 13-cis Retinoic Acid and Melatonin on the Viabilities of SH-SY5Y Neuroblastoma Cell Line

Tosun M, Soysal Y, Mas NG, Karabekir

OBJECTIVE: Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects...
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Effects of Physical Activity and Melatonin in a Rat Model of Depression Induced by Chronic Stress

Seong HH, Jung SM, Kim SW, Kim YJ

PURPOSE: Stress, depending on its intensity and duration, results in either adaptive or maladaptive physiological and psychological changes in humans. Also, it was found that stressful experiences increase the signs...
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The Effect of Combination Treatment of Melatonin and Hypothermia on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Park JH, Kim CS, Lee SL, Lee SR

PURPOSE: Melatonin is a naturally occurring hormone produced by the pineal gland. Melatonin has many pharmacological effects in different tissues or organs. Melatonin is especially known to have antioxidant and...
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Effects of Melatonin on MDPC-23 Cells Differentiation

Park JC, Shin IC, Lee DS, Yoon SH, Yang JH, Kim SB, Kim HJ

  • KMID: 2376071
  • Korean J Phys Anthropol.
  • 2007 Jun;20(2):105-113.
Melatonin is the major hormone released from the pineal gland and regulates a variety of physiological and pathophysiological processes. According to the recent studies the melatonin plays an important role...
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Melatonin Therapy for REM Sleep Behavior Disorder with Co-existing Moderate-to-Severe Sleep Apnea

Yun CH, Ji KH, Ha CK

  • KMID: 1527864
  • J Korean Neurol Assoc.
  • 2007 May;25(2):187-193.
BACKGROUND: REM sleep behavior disorder (RBD) commonly occurs in old-age group and shows very good response to clonazepam. However, clonazepam can aggravate or even precipitate sleep-disordered breathings (SDBs) that is...
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