J Korean Soc Biol Psychiatry.  1997 Nov;4(2):188-193.

Role of Serotonin in the Pathology and Treatment of Violence and Suicide

• Chung IW

Abstract

Along with psychosocial factors of suicide, biological backgrounds of suicide are explored by extensive works mostly on biological markers, neurobiological models, genetic bases, and relationship with aggression and violence. The biology of suicide confers on neurotransmitters in central nervous system exploring metabolites, receptor binding affinities, neuroen-docrine challenge tests in brain, cerebrospinal fluid, blood and etc. The major concerns with suicide are focused mainly on serotomin system: low CSF-5-HIAA concentration, higher 5-HT2 receptor binding, and blunt prolactin response to fenfluramine. Postmortem study, in vivo study, genetic contributions, and some other issues such as suicidal methods, serum cholesteral, alcohol, and selective serotonin reuptake inhibitors are reviewed and discussed.

MeSH Terms

Aggression
Biomarkers
Biology
Brain
Central Nervous System
Cerebrospinal Fluid
Fenfluramine
Models, Genetic
Neurotransmitter Agents
Pathology*
Prolactin
Psychology
Serotonin Uptake Inhibitors
Serotonin*
Suicide*
Violence*
Fenfluramine
Neurotransmitter Agents
Prolactin
Serotonin
Serotonin Uptake Inhibitors