J Lung Cancer.  2008 Dec;7(2):59-64. 10.6058/jlc.2008.7.2.59.

Alterations of the Apoptosis Genes and Their Products in Non-small Cell Lung Cancer Tissues

• Yoo NJ
• Lee SH

• KMID: 2200027
• DOI: http://doi.org/10.6058/jlc.2008.7.2.59

Abstract

Apoptosis is a principal type of cell death, and it has a profound effect on the development of cancer. It is also well known that anti-cancer agents induce apoptosis, and defects in the apoptosis pathways reduce the treatment sensitivity. Of the many pathways that induce apoptosis, the mechanisms of the intrinsic and extrinsic apoptosis pathways are well established. Non-small cell lung cancer (NSCLC) is a leading cause of cancer death worldwide, yet the exact molecular mechanisms of its development remain unclear. Apoptosis deregulations may underlie the development and pathogenesis of NSCLC. This review discusses the general mechanisms of apoptosis, the constituents of the apoptosis machinery and the alterations of the apoptosis-related genes in NSCLC

Keyword

Non-small cell lung cancer; Apoptosis; Mutation; Expression

MeSH Terms

Apoptosis
Carcinoma, Non-Small-Cell Lung
Cell Death