- Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET
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Lee JY, Kang BY, Jung SJ, Kwak AW, Lee SO, Park JW, Joo SH, Yoon G, Lee MH, Shim JH
- KMID: 2539589
- Biomol Ther.
- 2023 Mar;31(2):200-209.
- doi: 10.4062/biomolther.2022.113
Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive muta-tions initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective... -
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- Real-World Study of Osimertinib in Korean Patients with Epidermal Growth Factor Receptor T790M Mutation–Positive Non–Small Cell Lung Cancer
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Lee JH, Kim EY, Park CK, Lee SY, Lee Mk, Yoon SH, Lee JE, Lee SH, Kim SJ, Lee SY, Lim JH, Jang TW, Jang SH, Lee KY, Lee SH, Yang SH, Park DW, Park CK, Kang HS, Yeo CD, Choi CM, Lee JC
- KMID: 2537997
- Cancer Res Treat.
- 2023 Jan;55(1):112-122.
- doi: 10.4143/crt.2022.381
Purpose Although osimertinib is the standard-of-care treatment of epidermal growth factor receptor (EGFR) T790M mutation–positive non–small cell lung cancer, real-world evidence on the efficacy of osimertinib is not enough to... -
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- Lazertinib: on the Way to Its Throne
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Lee J, Hong MH, Cho BC
- KMID: 2532714
- Yonsei Med J.
- 2022 Sep;63(9):799-805.
- doi: 10.3349/ymj.2022.63.9.799
Lazertinib is an oral, irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that forms an irreversible covalent bond to the Cys797 residue in the ATP-binding site of... -
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- Clinical Efficacy of Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer Patients with Liver Metastases: A Network Meta-Analysis of Nine Randomized Controlled Trials
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Yin Q, Dai L, Sun R, Ke P, Liu L, Jiang B
- KMID: 2531326
- Cancer Res Treat.
- 2022 Jul;54(3):803-816.
- doi: 10.4143/crt.2021.764
Purpose This network meta-analysis (NMA) was conducted to compare the efficacy of immune checkpoint inhibitors in advanced non–small cell lung cancer (NSCLC) patients with liver metastases. Materials and Methods English literature... -
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- Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
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Lee S, Noh OK
- KMID: 2527627
- Radiat Oncol J.
- 2022 Mar;40(1):37-44.
- doi: 10.3857/roj.2021.00969
Purpose: This study aimed to identify the clinical parameters having the beneficial effect of postoperative radiotherapy (PORT) in pathologic N2 (pN2) non-small cell lung cancer (NSCLC) using the Surveillance, Epidemiology,... -
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- ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model
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Lee JM, Kim HS, Kim A, Chang YS, Lee JG, Cho J, Kim EY
- KMID: 2523329
- Yonsei Med J.
- 2022 Jan;63(1):16-25.
- doi: 10.3349/ymj.2022.63.1.16
Purpose: Tumor radioresistance and dose-limiting toxicity restrict the curative potential of radiotherapy, requiring novel approaches to overcome the limitations and augment the efficacy. Here, we investigated the effects of signal... -
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- Guidelines for the Investigation and Management of Ground Glass Nodules
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Lee JH, Hong JI, Kim HK
- KMID: 2521099
- J Chest Surg.
- 2021 Oct;54(5):333-337.
- doi: 10.5090/jcs.21.021
The clinical significance of ground-glass nodules (GGNs) has been investigated in extensive clinical research for many years. The natural history of GGNs is known to be closely related to their... -
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- Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects
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Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG
- KMID: 2525614
- Transl Clin Pharmacol.
- 2021 Sep;29(3):171-179.
- doi: 10.12793/tcp.2021.29.e17
Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered... -
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- Salvage radiation therapy for postoperative locoregionally recurrent non-small cell lung cancer: a single-center experience
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Jo YY, Kim SS, Song SY, Choi EK
- KMID: 2520457
- Radiat Oncol J.
- 2021 Sep;39(3):210-218.
- doi: 10.3857/roj.2021.00696
Purpose: To determine the effectiveness of salvage radiation therapy (RT) in patients with locoregional recurrence (LRR) following initial curative resection of non-small cell lung cancer (NSCLC) and identify the prognostic... -
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- Robot-Assisted Thoracic Surgery in Non-small Cell Lung Cancer
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Lee JH, Hong JI, Kim HK
- KMID: 2519137
- J Chest Surg.
- 2021 Aug;54(4):266-278.
- doi: 10.5090/jcs.21.070
Lobectomy is the standard treatment for early non-small cell lung cancer. Various surgical techniques for lobectomy have been developed, and minimally invasive thoracic surgery, such as video-assisted thoracic surgery or... -
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- Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
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Nam CH, Koh J, Ock CY, Kim M, Keam B, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS
- KMID: 2517814
- Korean J Intern Med.
- 2021 Jul;36(4):975-984.
- doi: 10.3904/kjim.2020.178
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer. Methods:... -
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- Surgical Impacts of Metastatic Nonsmall Cell Lung Cancer to the Thoracic and Lumbar Spine
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Jung Jm, Hyun SJ, Kim KJ
- KMID: 2513074
- J Korean Med Sci.
- 2021 Feb;36(7):e52.
- doi: 10.3346/jkms.2021.36.e52
Background: Surgery for spinal metastasis is rapidly increasing in frequency with procedures ranging from laminectomy to spondylectomy combined with stabilization. This study investigated the effect of various surgical procedures for... -
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- Rapidly Destructive Arthrosis of Knee Following Treatment of Crizotinib in a Patient with Non-Small-Cell Lung Cancer
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Hwang JT, Choi JH, Park CH, Yoon KJ, Lee YT, Do JG
- KMID: 2510189
- Clin Pain.
- 2020 Dec;19(2):120-123.
- doi: 10.35827/cp.2020.19.2.120
Rapidly destructive arthrosis is a rare syndrome characterized by narrowing of the joint space and rapid joint destruction within 6∼12 months. A 62-year-old woman with anaplastic lymphoma kinase rearranged non-small-cell... -
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- Incidental Lung Cancer of Explanted Lungs from Lung Transplant Recipients: Incidence, Characteristics, and 5-Year Survival
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Choi YJ, Kim SY, Park MS, Lee JG, Paik HC, Lee SH
- KMID: 2507812
- Yonsei Med J.
- 2020 Nov;61(11):958-964.
- doi: 10.3349/ymj.2020.61.11.958
Purpose: Recent history of malignancy without 5-year disease-free interval is an absolute contraindication for lung transplantation (LTx). However, in rare cases, lung cancer may be incidentally diagnosed in the explanted... -
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- The Effect of Epidermal Growth Factor Receptor Mutation on Intracranial Progression-Free Survival of Non-Small Cell Lung Cancer Patients with Brain Metastasis Underwent Gamma Knife Radiosurgery
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Yang SH, Kim HY, Lee Si, Jin SJ
- KMID: 2507785
- Brain Tumor Res Treat.
- 2020 Oct;8(2):e15.
- doi: 10.14791/btrt.2020.8.e15
Background The aim of this study was to survey prognostic factors, particularly those focusing on epidermal growth factor receptor (EGFR) mutations, of patients with non-small cell lung cancer (NSCLC) after... -
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- Induction of cytoprotective autophagy by morusin via AMP-activated protein kinase activation in human non-small cell lung cancer cells
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Park HJ, Park SH
- KMID: 2506885
- Nutr Res Pract.
- 2020 Oct;14(5):478-489.
- doi: 10.4162/nrp.2020.14.5.478
BACKGROUND/OBJECTIVES: Morusin, a marker component of Morus alba L., possesses anticancer activity. The objective of this study was to determine autophagy-inducing effect of morusin in non-small cell lung cancer (NSCLC)... -
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- EGFR C797S as a Resistance Mechanism of Lazertinib in Non-small Cell Lung Cancer with EGFR T790M Mutation
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Park S, Ku BM, Jung HA, Sun JM, Ahn JS, Lee SH, Park K, Ahn MJ
- KMID: 2507954
- Cancer Res Treat.
- 2020 Oct;52(4):1288-1290.
- doi: 10.4143/crt.2020.278
The non-small cell lung cancer with activating epidermal growth factor receptor (EGFR) mutation eventually acquires resistant to either first or second-generation EGFR tyrosine kinase inhibitor (TKI). As the following option,... -
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- Real-World Experience of Nivolumab in Non-small Cell Lung Cancer in Korea
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Lim SM, Kim SW, Cho BC, Kang JH, Ahn MJ, Kim DW, Kim YC, Lee JS, Lee JS, Lee SY, Park KU, An HJ, Cho EK, Jang TW, Kim BS, Kim JH, Lee SS, Na II, Yoo SS, Lee KH
- KMID: 2507937
- Cancer Res Treat.
- 2020 Oct;52(4):1112-1119.
- doi: 10.4143/crt.2020.245
Purpose The introduction of immune checkpoint inhibitors represents a major advance in the treatment of lung cancer, allowing sustained recovery in a significant proportion of patients. Nivolumab is a monoclonal anti–programmed... -
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- Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway
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Pan L, Tan Y, Wang B, Qiu W, Yin Y, Ge H, Zhu H
- KMID: 2504466
- Cancer Res Treat.
- 2020 Jul;52(3):867-885.
- doi: 10.4143/crt.2019.606
Purpose Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant... -
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- Absence of Clinical Value of TZAP Mutation and Expression in Non-small Cell Lung Cancers
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Lee DH, Jung SJ, Lee JH
- KMID: 2502847
- Keimyung Med J.
- 2020 Jun;39(1):23-27.
- doi: 10.46308/kmj.2020.00108
The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However,... -
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