J Korean Soc Ther Radiol.  1993 Jun;11(1):97-102.

The Results of Radiation Therapy of Limited Stage Small Cell Lung Cancer

• Kim SH
• Choi BO
• Gil HJ
• Yoon SC
• Bahk YW
• Shinn KS
• Kim HK
• Lee KS

Abstract

A retrospective analysis of various characteristics in 32 limited stage small cell lung cancer patients treated at the Department of Therapeutic Radiology in Kangnam ST. Mary's Hospital, Catholic University Medical College from April 1983 to September 1991, was carried out to identify factors which had prognostic signficance for survival from intiation of radiation therapy. There were 26 men and 6 women. Median age was 63 years )range:24-78 years). The follow up duration was 1.5 to 44 months(median:9 months). External radiation therapy was done with daily 160-180 cGy, 5 fraction/week, total of 1000-6660 cGy (median: 4500 cGy) to the mediatinum by 6 MY linear accelerator. Of 32 patients, 27 (84.4%) patients were treated with combined modality (chemotheraphy plus radiation therapy), and 5 (15.6%) patients were treated with radiation theraphy only. Complete responders were 12 patients (37.5%), partial responders were 11(34.4%), and no responders were 9(28.1%). Karnofsky performance status over 70(p< 0.007), chemotherapy regimen (CAV, PV, and CAV+PV) (p<0.04), 6 or more cycles of chemotherapy (p<0.007), radiation therapy over 4500 cGy (p<0.03), and radiation therapy responder (CR+PR) (p<0.003) showed a significantly favorable influence on 1 year survival rate. Age (p=0.545), sex (p=0.666), presence of superior vena cava syndrome (p=0.719), prophylactic cranial irradiation (p=0.217), and radiation therapy duration (p=0.491) had no effect on survival. Radiation induced side effects were transient esophagitis in 11(34%), general weakness in 9(28%), gastrointestianl sysptoms in terms of nausea, vomiting and indigestion in 5(15%) and leukopenia in 1(3%).

Keyword

Radiation Therapy; Limited Stage Small Cell Lung Cancer

MeSH Terms

Cranial Irradiation
Drug Therapy
Dyspepsia
Esophagitis
Female
Follow-Up Studies
Humans
Karnofsky Performance Status
Leukopenia
Male
Nausea
Particle Accelerators
Radiation Oncology
Retrospective Studies
Small Cell Lung Carcinoma*
Superior Vena Cava Syndrome
Survival Rate
Vomiting