J Korean Soc Pediatr Endocrinol.  2010 Dec;15(3):187-192.

Predictive Factors of Diabetes and Hypertension in Adult Turner Syndrome

• Jin HY
• Choi JH
• Lee BH
• Yoo HW

Abstract

PURPOSE
The risk of cardiovascular diseases (CVD) including hypertension, artherosclerosis and endocrinologic diseases such as thyroid disease, obesity, diabetes mellitus are elevated in adult Turner syndrome (TS). Clinical and biochemical parameters of TS patients were analyzed to investigate the predictive factors of diabetes and hypertension.
METHODS
Twenty nine patients with TS were enrolled in this study. Clinical and biochemical parameters including height, weight, body mass index (BMI), blood pressure, waist and hip circumferences, lipid profile, insulin, fasting glucose, and HbA1c were retrospectively reviewed.
RESULTS
Seven (24.1%) out of 29 had either impaired fasting glucose (IFG) or diabetes, 3 (10.3%) had central obesity, 5 (17.2%) had hypertriglyceridemia, 4 (13.8%) had low HDL cholesterol, 6 (20.7%) had hypertension, and 3 (10.3%) out of 29 were consistent with the criteria of MS. The waist circumference was longer in patients with either IFG or diabetes (67.1 +/- 5.4 cm vs. 79.4 +/- 8.3 cm, P = 0.009). Insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and adipokine levels were not significantly different according to the presence of either IFG or diabetes. Among TS patients, BMI was higher in patients with hypertension (26.2 +/- 5.7 kg/m2 vs. 22.5 +/- 3.1 kg/m2, P = 0.042). Total cholesterol exhibited a significant difference between patients with hypertension and those without hypertension (177.3 +/- 29.6 mg/dL vs. 222.8 +/- 28.5 mg/dL, P = 0.004).
CONCLUSION
Adult TS patients should be carefully followed regarding the development of diabetes and hypertension in case of severe central obesity and dyslipidemia.

Keyword

Turner syndrome; Metabolic syndrome; Hypertension; Diabetes mellitus

MeSH Terms

Adipokines
Adult
Blood Pressure
Body Weight
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Diabetes Mellitus
Dyslipidemias
Fasting
Glucose
Hip
Homeostasis
Humans
Hypertension
Hypertriglyceridemia
Insulin
Obesity
Obesity, Abdominal
Retrospective Studies
Thyroid Diseases
Turner Syndrome
Waist Circumference
Adipokines
Cholesterol
Cholesterol, HDL
Glucose
Insulin