J Korean Assoc Maxillofac Plast Reconstr Surg.  1998 Nov;20(4):379-382.

Radiation-induced osteosarcoma: report of a case

• Park KS
• Lee YG
• Park HS
• Kim JB

Abstract

The 44 years old man was consulted to our department due to restriction of mouth opening. On radiograph, we found bony expansive lesion at right mandibular ramus and temporal bone that it was suspected malignant tumor. So we had performed incisional bone biopsy at right ramus through skin incision. The result of biopsy was osteosarcoma. Then, he had expericenced radiation therapy for the protection of recurrence after several times surgery of nasopharyngeal angiofibroma, 28 years ago. So, we concluded radiation induced osteosarcoma from his radiation therapy history. He had refered to the department of hematooncology because of severe expasion to skull base and was received 4 times chemotherapy with cisplatin and adriamycin, but he was expired just after 4th chemotherapy. Such radiation induced osteosarcoma have relative good prognosis due to rare metastasis from other reports. So if it will early detect from close follow up after radiation therapy, survival rate will rise up. But we missed early detection of our case. So, we report a case of rare radiation induced osteosarcoma.

Keyword

Radiation-induced osteosarcoma; Radiation therapy

MeSH Terms

Adult
Angiofibroma
Biopsy
Cisplatin
Doxorubicin
Drug Therapy
Follow-Up Studies
Humans
Mouth
Neoplasm Metastasis
Osteosarcoma*
Prognosis
Recurrence
Skin
Skull Base
Survival Rate
Temporal Bone
Cisplatin
Doxorubicin