Brain Tumor Res Treat.  2015 Oct;3(2):156-159. 10.14791/btrt.2015.3.2.156.

A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma

Affiliations
  • 1Neuro-Oncology Clinic, Center for Specific Organs Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Korea. nslsh@ncc.re.kr

Abstract

Radiation therapy has an important role in postoperative treatment of neoplasms originated from central nervous system, but may induce secondary malignancies like as sarcomas, gliomas, and meningiomas. The prognosis of radiation-induced osteosarcomas is known as poor, because they has aggressive nature invasive locally and intractable to multiple treatment strategies like as surgical resection, chemotherapy, and so on. We report a case of radiation-induced osteosarcoma developed from skull after 7 years of craniospinal radiotherapy for pineoblastoma.

Keyword

Radiation; Osteosarcoma; Irradiation; Skull; Pineoblastoma

MeSH Terms

Central Nervous System
Drug Therapy
Glioma
Meningioma
Osteosarcoma*
Pinealoma*
Prognosis
Radiotherapy
Sarcoma
Skull

Figure

  • Fig. 1 Radiation treatment plan.

  • Fig. 2 Pathologic finding of tumor specimen. There were two parts, dura and scalp. A and B were removed from epidural layer including dura mater (A: H&E, ×4, B: H&E, ×200). The features shown that pleomorphic single cells with abundant cytoplasm and prominent nucleoli, osteoid production are compatible with osteoblastic osteosarcoma. H&E, hematoxylin and eosin.

  • Fig. 3 T1-weighted MRI with gadolinium-enhancement shows irregular enhancing mass at mainly Rt. frontal area and extending to contralateral side. A, B, and C are each applicable to axial, coronal, and sagittal view.


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